ymjЯкутский медицинский журналYakut Medical Journal1813-19052312-1017ЯНЦ КМП10.1234/YMJ.2022.77.27ymj-168Research ArticleНАУЧНЫЕ ОБЗОРЫ И ЛЕКЦИИSCIENTIFIC REVIEWS AND LECTURESГены-маркеры язвенной болезниGenes-markers of peptic ulcer diseasehttps://orcid.org/0000-0002-2922-7087СагадатоваЮ. Р.SagadatovaYu. R.

Сагадатова Юлия Риязовна – аспирант.

Уфа

Yuliya R. Sagadatova – Postgraduate student of the Department of Surgical Diseases.

https://orcid.org/0000-0001-5870-8894ХасановА. Г.KhasanovA. G.

Хасанов Анвар Гиниятович – д.м.н., проф., зав. кафедрой.

Уфа

Anvar G. Khasanov – Doctor of Medical Sciences, Professor, Head of the Department of Surgical Diseases.

ГилязоваИ. Р.GilyazovaI. R.

Гилязова Ирина Ришатовна – к.б.н., доцент, с.н.с. Института биохимии и генетики УФИЦ РАН.

Уфа

Irina R. Gilyazova – Candidate of Biological Sciences, Associate Professor of the Department of Medical Genetics and Fundamental Medicine of IDPO, senior research fellow.

https://orcid.org/0000-0003-2738-393XБадретдиновА. Ф.BadretdinovA. F.

Бадретдинов Азамат Фуатович – к.м.н., доцент.

Уфа

Azamat F. Badretdinov – Candidate of Medical Sciences, Associate Professor of the Department of Surgical Diseases.

https://orcid.org/0000-0003-1890-2865ФаязовР. Р.FayazovR. R.

Фаязов Радик Радифович – д.м.н., проф.

Уфа

Radik R. Fayazov – Doctor of Medical Sciences, Professor of the Department of Surgical Diseases.

https://orcid.org/0000-0001-8688-8458СуфияровИ. Ф.SufiyarovI. F.

Суфияров Ильдар Фанусович – д.м.н., проф., декан педиатрич. факультета.

Уфа

Ildar F. Sufiyarov – Doctor of Medical Sciences, Professor of the Department of Surgical Diseases, Dean of the Faculty of Pediatrics.

Башкирский ГМУRussian FederationУФИЦ РАНRussian Federation20220502202501108111Copyright © Сагадатова Ю.Р., Хасанов А.Г., Гилязова И.Р., Бадретдинов А.Ф., Фаязов Р.Р., Суфияров И.Ф., 20252025Сагадатова Ю.Р., Хасанов А.Г., Гилязова И.Р., Бадретдинов А.Ф., Фаязов Р.Р., Суфияров И.Ф.Sagadatova Y.R., Khasanov A.G., Gilyazova I.R., Badretdinov A.F., Fayazov R.R., Sufiyarov I.F.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://ymj.elpub.ru/jour/article/view/168

Представлен анализ литературы по исследованиям, посвященным изучению генов–кандидатов язвенной болезни. Все материалы данных публикаций можно объединить в две большие группы: исследования, посвященные изучению генов-индукторов язвенной болезни, и исследования, посвященные генам-протекторам.

The review presents the analysis of the literature on genetic studies devoted to candidate genes for peptic ulcer disease. All the materials of these publications can be combined into two large groups: studies devoted to investigation of peptic ulcer inducer genes and studies devoted to protective genes. The main groups of ulcer inducer genes (ABO, HLA, PSCA, IL-1B, IL1RN, IL-6, IL-8, IL-10, TNFα, TGF-b1, B1,2,3, CYP2C19, MMP-2, MMP-3, MMP-9, Toll,TLR4TLR9, MIF, MPO) and protectors (IL-1, IL-1RN, TNF, LTA, IL-1b, MMP-3) were identified, but most of the results obtained to date are inconsistent, poorly reproduced in ethnically diverse populations, which makes it relevant to study this problem among different groups living in the Russian Federation.

язвенная болезнь желудка и двенадцатиперстной кишкигены-маркеры язвенной болезниpeptic ulcer in womenpeptic ulcer of the stomach and duodenumgenesgenes-markers of peptic ulcer diseaseliterature reviewReferencesАссоциации полиморфных вариантов генов цитокинов с риском развития язвенной болезни в республике Башкортостан / А.Х. Нургалиева, Э.Х. Шаймарданова, И.М. Хидиятова. [и др.] // Генетика. – 2014. – Т. 50. – № 12. – С. 1455.Associations of polymorphic variants of cytokine genes with the risk of developing peptic ulcer disease in the Republic of Bashkortostan / A.H. Nurgalieva, E.H. Shaimardanova, I.M. Hidiyatova. [et al.] // Genetics. - 2014. - V. 50. – No 12. - p. 1455.Валова Я.В. Факторы риска развития язвенной болезни. Актуальные вопросы экологии человека / Я.В. Валова // Сборник научных статей участников Всероссийской научно-практической конференции с международным участием: в 3-х томах. – 2015 – С. 41-46.Valova Y.V. Risk factors in the development of ulcer disease. Topical issues of human ecolog/ Y.V. Valova // Collection of scientific articles of participants of the All-Russian Scientific and practical conference with international participation: in 3 volumes. – 2015 – P. 41-46.Садыкова К.Ж., /Генетические предикторы осложненного течения язвенной болезни / К.Ж. Садыкова, Б.Ж. Рахимбеков // Интернаука. – 2020 – T. 19 - № 1(148). – С. 65-66.Sadykova K.G., / Genetic predictors of the complicated course of peptic ulcer disease / K.G. Sadykova, B.G. Rakhimbekov // Internayka. – 2020. – V.19. – No 1(148). – P. 65-66Характеристика наследственной предрасположенности при язвенной болезни двенадцатиперстной кишки / Л.В. Волевач, Л.В Габбасова, О.А Курамшина. [и др.]. // Современные проблемы науки и образования. – 2017. – № 5.Characteristics of hereditary predisposition in duodenal ulcer / L.V. Volevach, L.V. Gabbasova, O.A. Kuramshina. [et al.]. // Modern problems of science and education. – 2017. – No 5Язвенная болезнь у женщин. / Ю.Р. Сагадатова, А.Г. Хасанов, И.Ф. Суфияров [и др] // Экспериментальная и клиническая гастроэнтерология.- 2021. - №8. – С. 160-166. Doi: 10.31146/1682-8658-ecg-192-8-160-166Pulcer disease in women. / Yu.R. Sagadatova, A.G. Khasanov, I.F. Sufiyarov [et al.] // Experimental and Clinical Gastroenterology. – 2021. - №8. – P. 160-166. Doi: 10.31146/1682-8658-ecg-192-8-160-166Яриев А.А. / Полиморфизм RS1800471 гена TGFB1 в формировании предрасположенности к язвенной болезни двенадцатиперстной кишки и хронического гастрита / А.А. Яриев, Х.Я. Каримов, А.Т. Бабаев // Вестник неотложной и восстановительной хирургии. – 2018. – Т.3. – №. 3. – С. 289-297.Yariev A.A. / Polymorphism RS1800471 of the TGFB1 gene in the formation of predisposition to duodenal ulcer and chronic gastritis / A.A. Yariev, H.Ya., Karimov, A.T. Babaev // Bulletin of Emergency and Reconstructive Surgery. - 2018. - V. 3. - No 3. - P. 289-297.A primer on cytokines / P. Chauhan, A. Nair, A. Patidar [et al.] //Cytokine. 2021;145:155458. DOI: 10.1016/j.cyto.2021.155458A primer on cytokines / P. Chauhan, A. Nair, A. Patidar [et al.] //Cytokine. 2021;145:155458. DOI: 10.1016/j.cyto.2021.155458American College of Gastroenterology and Canadian Association of Gastroenterology guidelines on the management of dyspepsia // P. Moayyedi, B.E. Lacy, С.N. Andrews [et al.]// Am J Gastroenterol.- 2017. – V.112. – P.988–1013. DOI: 10.1038/ajg.2017.154American College of Gastroenterology and Canadian Association of Gastroenterology guidelines on the management of dyspepsia // P. Moayyedi, B.E. Lacy, С.N. Andrews [et al.]// Am J Gastroenterol.- 2017. – V.112. – P.988–1013. DOI: 10.1038/ajg.2017.154An updated association between TNF-α-238G/A polymorphism and gastric cancer susceptibility in East Asians/ H. Zhao, L. Liu, B. Liu, [et al.]//Bioscience reports. – 2018. – V.38. – No 3. - BSR20181231 DOI: 10.1042/BSR20181231An updated association between TNF-α-238G/A polymorphism and gastric cancer susceptibility in East Asians/ H. Zhao, L. Liu, B. Liu, [et al.]//Bioscience reports. – 2018. – V.38. – No 3. - BSR20181231 DOI: 10.1042/BSR20181231Association between IL-1B gene polymorphisms and Helicobacter pylori infection: a meta-analysis/ Ren H.Y., Wen L.S., Geng Y.H. [et al.] //Microbial pathogenesis. – 2019. – V. 137. – P. 103769. DOI: 10.1016/j.micpath.2019.103769Association between IL-1B gene polymorphisms and Helicobacter pylori infection: a meta-analysis/ Ren H.Y., Wen L.S., Geng Y.H. [et al.] //Microbial pathogenesis. – 2019. – V. 137. – P. 103769. DOI: 10.1016/j.micpath.2019.103769Association of a single nucleotide polymorphism in the TLR2 gene (rs3804099), but not in the TLR4 gene (rs4986790), with Helicobacter pyloriinfection and peptic ulcer/ E. Mirkamandar, M. Nemati, M. Hayatbakhsh [et al.]// The Turkish Journal of Gastroenterology. – 2018. – V. 29. – No 3. – P. 283–291. DOI: 10.5152/tjg.2018.17484Association of a single nucleotide polymorphism in the TLR2 gene (rs3804099), but not in the TLR4 gene (rs4986790), with Helicobacter pyloriinfection and peptic ulcer/ E. Mirkamandar, M. Nemati, M. Hayatbakhsh [et al.]// The Turkish Journal of Gastroenterology. – 2018. – V. 29. – No 3. – P. 283–291. DOI: 10.5152/tjg.2018.17484Association of Helicobacter pyloriinfection with Toll-like receptor-4 Th r399Ile polymorphism increased the risk of peptic ulcer development in North of Iran / M. Tourani, M. Habibzadeh, J. Shokri-Shirvani [et al.] //Journal of Pathology, Microbiology and Immunology. – 2017. – V.126. – No 1. – P.76–84. DOI: 10.1111/apm.12779Association of Helicobacter pyloriinfection with Toll-like receptor-4 Th r399Ile polymorphism increased the risk of peptic ulcer development in North of Iran / M. Tourani, M. Habibzadeh, J. Shokri-Shirvani [et al.] //Journal of Pathology, Microbiology and Immunology. – 2017. – V.126. – No 1. – P.76–84. DOI: 10.1111/apm.12779Association of heterogenicity of Helicobacter pylori cag pathogenicity island with peptic ulcer diseases and gastric cancer / Khatoon, J., Prasad, K. N., Prakash Rai [et al.]// British journal of biomedical science. – 2017. – V. 74. – No 3. – P. 121-126.Association of heterogenicity of Helicobacter pylori cag pathogenicity island with peptic ulcer diseases and gastric cancer / Khatoon, J., Prasad, K. N., Prakash Rai [et al.]// British journal of biomedical science. – 2017. – V. 74. – No 3. – P. 121-126.Association of IL-1B+3954 and IL-1RN Polymorphisms in Chronic Gastritis and Peptic Ulcer / R. N Motamedi, M. Rezaeishahmirzadi, S. Shakeri [et al.]// Iran J Public Health. – 2018. – V.47. – No 9. – P. 1364-1370.Association of IL-1B+3954 and IL-1RN Polymorphisms in Chronic Gastritis and Peptic Ulcer / R. N Motamedi, M. Rezaeishahmirzadi, S. Shakeri [et al.]// Iran J Public Health. – 2018. – V.47. – No 9. – P. 1364-1370.Association of the IL-1RN variable number of tandem repeat polymorphism and Helicobacter pylori infection: A meta-analysis/ J. Zhang, X. Sun, J. Wang, [et al.]//PloS one. 2017. – V.12. – No 4. - e0175052. DOI: 10.1371/journal.pone.0175052Association of the IL-1RN variable number of tandem repeat polymorphism and Helicobacter pylori infection: A meta-analysis/ J. Zhang, X. Sun, J. Wang, [et al.]//PloS one. 2017. – V.12. – No 4. - e0175052. DOI: 10.1371/journal.pone.0175052Correlation between expression of MMP-9 and MMP-3 in Helicobacter pylori infected patients with different gastroduodenal diseases/ N. Bagheri, M. Sadeghiani, G. Rahimian [et al]. //Arab journal of gastroenterology. – 2018. – Т. 19. – No 4. – С. 148-154. DOI: 10.1016/j.ajg.2018.11.001Correlation between expression of MMP-9 and MMP-3 in Helicobacter pylori infected patients with different gastroduodenal diseases/ N. Bagheri, M. Sadeghiani, G. Rahimian [et al]. //Arab journal of gastroenterology. – 2018. – Т. 19. – No 4. – С. 148-154. DOI: 10.1016/j.ajg.2018.11.001Frank S. A. Immunology and evolution of infectious disease / S. A. Frank // Princeton University Press. - 2020. DOI: 10.1515/9780691220161Frank S. A. Immunology and evolution of infectious disease / S. A. Frank // Princeton University Press. - 2020. DOI: 10.1515/9780691220161Gonzalez-Hormazabal P. IL-8-251T> A (rs4073) polymorphism is associated with prognosis in gastric cancer patients/ P. Gonzalez-Hormazabal, S. Romero, M. Musleh [et al.] //Anticancer research. - 2018.- V. 38. – No 10. – P. 5703-5708. DOI: DOI: 10.21873/anticanres.12907Gonzalez-Hormazabal P. IL-8-251T> A (rs4073) polymorphism is associated with prognosis in gastric cancer patients/ P. Gonzalez-Hormazabal, S. Romero, M. Musleh [et al.] //Anticancer research. - 2018.- V. 38. – No 10. – P. 5703-5708. DOI: DOI: 10.21873/anticanres.12907Impact of PSCA polymorphism on the risk of duodenal ulcer / Y. Usui, K. Matsuo, I. Ozeet [et al.]// Journal of epidemiology. - 2019 DOI: 10.2188/jea.JE20190184(65)Impact of PSCA polymorphism on the risk of duodenal ulcer / Y. Usui, K. Matsuo, I. Ozeet [et al.]// Journal of epidemiology. - 2019 DOI: 10.2188/jea.JE20190184(65)Interleukin-1β and Interleukin-1 receptor antagonist gene polymorphism in pediatric patients with Helicobacter pylori-associated chronic gastritis / S.H. Barakat, M.A. Meheissen, S.M. El-Gendi [et al.]//Journal of Tropical Pediatrics. – 2021. – V.67. – P. 3. DOI: 10.1093/tropej/fmab061Interleukin-1β and Interleukin-1 receptor antagonist gene polymorphism in pediatric patients with Helicobacter pylori-associated chronic gastritis / S.H. Barakat, M.A. Meheissen, S.M. El-Gendi [et al.]//Journal of Tropical Pediatrics. – 2021. – V.67. – P. 3. DOI: 10.1093/tropej/fmab061Kany S. Cytokines in inflammatory disease/ S. Kany, J. T. Vollrath, B. Relja //International journal of molecular sciences. – 2019. – V.20. – No 23. - P. 6008. DOI:10.3390/ijms20236008Kany S. Cytokines in inflammatory disease/ S. Kany, J. T. Vollrath, B. Relja //International journal of molecular sciences. – 2019. – V.20. – No 23. - P. 6008. DOI:10.3390/ijms20236008Lanas A. Peptic ulcer disease / A. Lanas, F. K.L Chan // The Lancet. – 2017. – V.390. – No 10094. – P. 613-624. DOI: 10.1016/S0140-6736(16)32404-7Lanas A. Peptic ulcer disease / A. Lanas, F. K.L Chan // The Lancet. – 2017. – V.390. – No 10094. – P. 613-624. DOI: 10.1016/S0140-6736(16)32404-7Low pepsinogen I/II ratio and high gastrin-17 levels typify chronic atrophic autoimmune gastritis patients with gastric neuroendocrine tumors/ R. Magris, V. De Re, S. Maiero, [et al.]//Clinical and Translational Gastroenterology. – 2020. – V.11. – No 9. DOI: 10.14309/ctg.0000000000000238Low pepsinogen I/II ratio and high gastrin-17 levels typify chronic atrophic autoimmune gastritis patients with gastric neuroendocrine tumors/ R. Magris, V. De Re, S. Maiero, [et al.]//Clinical and Translational Gastroenterology. – 2020. – V.11. – No 9. DOI: 10.14309/ctg.0000000000000238Management of Helicobacter pylori infection– the Maastricht V / P. Malfertheiner, F. Megraud, C. O’Morain [et al.]//Florence Consensus. Report. – 2017. – V.66. - №1. – P. 6–30.Management of Helicobacter pylori infection– the Maastricht V / P. Malfertheiner, F. Megraud, C. O’Morain [et al.]//Florence Consensus. Report. – 2017. – V.66. - №1. – P. 6–30.Miftahussurur, M. Helicobacter pylori virulence genes and host genetic polymorphisms as risk factors for peptic ulcer disease./ M. Miftahussurur, Y. Yamaoka // Expert Rev Gastroenterol Hepatol. – 2015. – V. 9. – No 12. – P. 1535-47. doi: 10.1586/17474124.2015.1095089.Miftahussurur, M. Helicobacter pylori virulence genes and host genetic polymorphisms as risk factors for peptic ulcer disease./ M. Miftahussurur, Y. Yamaoka // Expert Rev Gastroenterol Hepatol. – 2015. – V. 9. – No 12. – P. 1535-47. doi: 10.1586/17474124.2015.1095089.Minyaylo, O. Functionally significant polymorphisms of the MMP-9 gene are associated with peptic ulcer disease in the Caucasian population of Central Russia / O. Minyaylo, I. Ponomarenko, E. Reshetnicov //Scientific reports. – 2021. – V. 11. – No 1. – P. 1-8.Minyaylo, O. Functionally significant polymorphisms of the MMP-9 gene are associated with peptic ulcer disease in the Caucasian population of Central Russia / O. Minyaylo, I. Ponomarenko, E. Reshetnicov //Scientific reports. – 2021. – V. 11. – No 1. – P. 1-8.Polymorphisms of the IL-6, IL-8 and IL-10 genes and the risk of gastric pathology in patients infected with Helicobacter pylori/ I.B. Ramis, J.S. Vianna, C.V. Gonçalves [et al.]//Journal of Microbiology, Immunology and Infection. – 2017. – V.50. – No 2. – P. 153-159. DOI: 10.1016/j.jmii.2015.03.002Polymorphisms of the IL-6, IL-8 and IL-10 genes and the risk of gastric pathology in patients infected with Helicobacter pylori/ I.B. Ramis, J.S. Vianna, C.V. Gonçalves [et al.]//Journal of Microbiology, Immunology and Infection. – 2017. – V.50. – No 2. – P. 153-159. DOI: 10.1016/j.jmii.2015.03.002Polymorphisms of Tumor Necrosis Factor Alpha in Moroccan Patients with Gastric Pathology: New Single-Nucleotide Polymorphisms in TNF-α (–193) (G/A)/ A. Essadik, H. Jouhadi, T. Rhouda// Mediators of Inflammation. - 2015. - 143941. DOI: 10.1155/2015/143941.Polymorphisms of Tumor Necrosis Factor Alpha in Moroccan Patients with Gastric Pathology: New Single-Nucleotide Polymorphisms in TNF-α (–193) (G/A)/ A. Essadik, H. Jouhadi, T. Rhouda// Mediators of Inflammation. - 2015. - 143941. DOI: 10.1155/2015/143941.The IL-1B genetic polymorphism is associated with aspirin-induced Peptic Ulcers in a Korean Ethnic Group. / J. H. Cho, J. S.Choi, S. W. Chun // Gut and Liver. – 2016. – V. 10. - №3. – P. 362.The IL-1B genetic polymorphism is associated with aspirin-induced Peptic Ulcers in a Korean Ethnic Group. / J. H. Cho, J. S.Choi, S. W. Chun // Gut and Liver. – 2016. – V. 10. - №3. – P. 362.Zeyaullah, M. Association of Helicobacter pylori Infection and Host Cytokine Gene Polymorphism with Gastric Cancer/M. Zeyaullah, A. M., AlShahrani, I. Ahmad.// Canadian Journal of Gastroenterology and Hepatology. - 2021. - DOI: 10.1155/2021/8810620Zeyaullah, M. Association of Helicobacter pylori Infection and Host Cytokine Gene Polymorphism with Gastric Cancer/M. Zeyaullah, A. M., AlShahrani, I. Ahmad.// Canadian Journal of Gastroenterology and Hepatology. - 2021. - DOI: 10.1155/2021/8810620

The authors declare that there are no conflicts of interest present.