ymjЯкутский медицинский журналYakut Medical Journal1813-19052312-1017ЯНЦ КМПymj-1655Research ArticleНАУЧНЫЕ ОБЗОРЫ И ЛЕКЦИИSCIENTIFIC REVIEWS AND LECTURESФакторы риска развития рака легкогоRisk factors for lung cancerАлександроваЕ. Н.AlexandrovaE. N.

Александрова Елена Николаевна – н.с.

Yakutsk, Republic Sakha (Yakutia)

НиколаевВ. М.NikolaevV. M.

Николаев Вячеслав Михайлович – с.н.с.

senior researcher

Yakutsk, Republic Sakha (Yakutia)

ИвановП. М.IvanovP. M.

Иванов Петр Михайлович – д.м.н., проф., зав. лаб.

MD, prof., head of lab.

Yakutsk, Republic Sakha (Yakutia)

petr_ivanov_38@mail.ruФГБНУ «ЯНЦ КМП»РоссияYSC CMPRussian Federation201620092025037983Copyright © Александрова Е.Н., Николаев В.М., Иванов П.М., 20252025Александрова Е.Н., Николаев В.М., Иванов П.М.Alexandrova E.N., Nikolaev V.M., Ivanov P.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://ymj.elpub.ru/jour/article/view/1655

Проведен анализ основных факторов риска развития рака легкого, таких как курение, в том числе пассивное, загрязнение производственной среды, атмосферного воздуха, ионизирующей радиации и др. Показано, что рак легкого можно отнести к социально значимым болезням, вопросы профилактики и лечения которых остаются нерешенными.

The analysis of the main risk factors for lung cancer, such as smoking, including passive one, industrial pollution of environment, air pollution, ionisated radiation and et al. It has been shown that lung cancer should be referred to a socially significant morbidity, prevention and treatment problems of which are not settled yet.

рак легкогофакторы рисказлокачественные новообразованияlung cancerrisk factorsmalignant tumorsReferencesБелосохов М.В. Патоморфологическая характеристика рака легкого у работников завода по производству плутония: автореф. дис. ... канд. мед. наук / М.В. Белосохов. – Челябинск, 2006. – 25 с.Belosokhov M.V. Pathomorphological characteristic of lung cancer of plant workers producing plutonium; synopsis of thesis,m.d. / M.V.Belosokhov. – Chelyabinsk, 2006. – Р. 25.Воробьев В.А. Эпидемиологические аспекты рака легкого в Томской области: дис. ... канд. мед. наук / В.А. Воробьев. – Томск, 2013. – 209 с.Vorobiev V.A. Epidemiological aspects of lung cancer in Tomsk region: dissert.m.s. / V.A. vorobiev. – Tomsk, 2013. – Р.209.Государственный доклад. О санитарноэпидемиологической обстановке в Российской Федерации в 2005 году. – М.: Федеральный центр гигиены и эпидемиологии Роспотребнадзора, 2006. – 289 с.State report. Sanitary-epidemiological situation in the Russian Federation in 2005. – M.: Federal centre of hygiene and epidemiology. Rusconssupervision, 2006. – Р. 289.Доклад «Об экологической ситуации в Республике Саха (Якутия) в 2011 году» / Министерство охраны природы РС (Я).– 2011 – Электрон, дан. – Режим доступа: http://www.adm@adm.sakha.gov.ru.Report “Ecological situation in the RS (Y) in 2011. / Ministry of nature and ecology in RS(Y)- 2011-elect. – http://www.adm.@adm.sakha.gov.ru.Заридзе Д.Г. Канцерогенез / Под ред. Д.Г. Заридзе. – М.: Медицина, 2004. – 576 с.Zaridze D.G. Carcinogenes / Edit.D.G. Zaridze. – M.: Medicine, 2004. – Р.576.Заридзе Д.Г. Профилактика рака. Руководство для врачей / Д.Г. Заридзе. – М.: ИМАПРЕСС, 2009. – 224 с.Zaridze D.G. Prophylaxis of cancer. Instruction for doctors / D.G. Zaridze. – M.: IMA-PRESS, 2009. – Р.224.Заридзе Д.Г. Эпидемиология и профилактика рака / Д.Г. Заридзе // Вопросы онкологии. – 2001. – № 9. – С. 6-14.Zaridze D.G. Epidemiology and prophylaxis of cancer / D.G.Zaridze // Questions of oncology. – 2001. – № 9. – Р.6-14.Земляная Г.М. Загрязнение воздуха жилых помещений радоном и риск развития рака легкого / Г.М. Земляная, Д.Г. Заридзе // Экспер. онкол. – 1991. – Т. 13, № 6. – С. 3-7.Zemlyanaya G.M. Air pollution by radon in dwelling houses and development of lung cancer risk / G.M. Zemlyanaya, D.G. Zaridze // Еxpert. oncol. – 1991. – V.13, №6. – Р. 3-7.Кириллова Э.В. Характеристика проявлений рака легкого на территориях, отличных по техногенным нагрузкам на атмосферный воздух / Э.В.Кириллова, Г.Е.Ефимов, В.Н.Ручкин // Креативная хирургия и онкология.– 2013. – №1-2.– С.10-16.Kirillova E.V. Characteristic of lung cancer in the territories of technogenic load / E.V. Kirillova, G.E. Efimov, V.N. Ruchkin [et al.] // Creative surgery and oclogy. – 2013.– № 1-2. – Р.10-16.Комлева В.А. Эпидемиологическое изучение онкологической заболеваемости в районах размещения ТЭС и АЭС / В.А. Комлева // Гигиена и санитария. – 1999. – № 1. – С. 10-13.Komleva V.A. Epidemiological research of oncological morbidity in the regions of HES and AES / V.A. Komleva // Hygiene and sanitation. – 1999. – №1. – Р.10-13.Михайлов Э.А. Исследование анамнеза курения у больных со злокачественными новообразованиями / Э.А. Михайлов, В.Ф. Левшин, А.Н. Горячева, Л.П. Цыбулина // Вестник РОНЦ им. Н. Н. Блохина РА МН. – 2009. – Т. 20, №1. – С. 36-42.Mikhailov E.A. Anamnesis research of smokers with malignant tumours / E.A. Mikhailov, V.F. Levshin, A.N. Goryacheva, L.P. Tsybulina // Vestnik ROSC named after N.N. Blokhin RAMS. – 2000.– V.20,№1. – Р.36-42.Мукерия А.Ф. Эпидемиология и профилактика рака легкого / А.Ф. Мукерия, Д.Г. Заридзе // Вестник РОНЦ им. Н. Н. Блохина РА МН. – 2010. – Т. 21, №3. – С. 3-13.Mukeriya A.F. Epidemiology and lung cancer prophylaxis / A.F. Mukeriya, D.G. Zaridze // Vestnik ROSC named after N.N. Blokhin RAMS. – 2010. – V.21,№3. – Р.3-13.Назиров Р.А. Снижение естественной радиоактивности цементных бетонов / Р.А. Назиров, Е.В. Пересыпкин, И.В. Тарасов, В.И. Верещагин // Изв. вузов. Строительство. – 2007. – № 1(577). – С.45.Nazirov R.A. Lowering of natural radio activity of cement concrete / R.A. Nazirov, E.V. Peresypkin, I.V. Tarasov, V.I. Vershagin // P.h. Stroitelstvo. – 2007. – № 1(577).– Р.45.Одинцова И.Н. Гигиенические аспекты формирования заболеваемости раком лёгкого в регионе Сибири и Дальнего Востока: автореф. дис. ... канд. мед. наук / И.Н. Одинцова. – Кемерово, 1999. – 25 с.Odintsova I.N. Hygienic aspects of morbidity with lung cancer in Siberia and Far East: synopsis of thesis. M.d. / I.N. Odintsova. – Kemerovo,1999. – Р.25.Писарева Л.Ф. Особенности онкологической заболеваемости населения Сибири и Дальнего Востока / Л.Ф. Писарева, А.П. Бояркина, P.M. Тахауов, А.Б. Карпов. – Томск: Издво Том. ун-та, 2001. – 411 с.Pisareva L.F. Peculiarities of oncological morbidity in Siberia and Far East / L.F. Pisareva, A.P. Boyarkina, R.M. Takhauov, A.B. Karpov. – Tomsk: N.H. Tom. Univ. 2001. – Р.411.Садовников А.А. Рак легкого на фоне посттуберкулезных изменений / А.А. Садовников, К.И. Панченко // Российский онкологический журнал. –2011. – №6. – С. 29-33.Sadovnikov A.A. Lung cancer against posttubercular changes / A.A. Sadovnikov, K.I. Panchenko // Russian oncological journal. – 2011. – № 6. – Р.29-33.Сидельникова О.П. Радиационная безопасность в зданиях: справочник / О.П. Сидельникова, И.В. Стефаненко, П.Э. Соколов. – М.: Энергоатомиздат, 2006. – 328 с.Sidelnikova O.P. Radiation safety in buildings: reference book / O.P. Sidelnikova, I.V. Stefanenko, P.E. Sokolov. – M.: Energoatomizdat, 2006. – Р.328.Суслин В.П. Человек, радон, строительные материалы / В.П. Суслин // Проектирование и строительство в Сибири. – 2002. – № 2(8). – С. 39-40.Suslin V.Р. Man, radon, building materials / V.P. Suslin // Projecting and construction in Siberia. – 2002. – №2(8). – Р.39-40.Чиссов В.И. Злокачественные новообразования в России в 2010 году (заболеваемость и смертность) / Под ред. В.И. Чиссова, В.В. Старинского, Г.В.Петровой. – М.: ФГУ «МНИИОИ им. П.А. Герцена Росмедтехнологий», 2012. – 260 с.Chissov V.I. Malignant tumors in Russia in 2010. (Morbidity and mortality) / Edit. V.I.Chissov, V.V. Starinksy, G.V. Petrova. – M.: MSRTON named after P.A. Hertsen «Rosmedtekhnologiya» 2012. – Р.260.Шабад Л.М. О циркуляции канцерогенов в окружающей среде / Л.М. Шабад. – М.: Медицина, 1973. – С. 35.Shabad L.M About circulation of carcinogens in environment /L.M.Shabad.-M.: Medicine, 1973.- p.35.Alberg A.J. Epidemiology of lung cancer: looking to the future / A.J. Alberg, M.V. Brock, J.M. Samet // J Clin. Oncol. – 2005. – Vol.23. – P. 3175 -3185.Alberg A.J. Epidemiology of lung cancer: looking to the future / A.J. Alberg, M.V. Brock, J.M. Samet // J Clin. Oncol. – 2005. – Vol.23. – P. 3175 -3185.Alberg A.J. Epidemiology of lung cancer: ACCP evidence-based clinical practice guidelines (2nd edition) / A.J. Alberg, J.G. Ford, J.M. Samet // Chest. –2007. – №132, Suppl. 3. – P. 29-55.Alberg A.J. Epidemiology of lung cancer: ACCP evidence-based clinical practice guidelines (2nd edition) / A.J. Alberg, J.G. Ford, J.M. Samet // Chest. –2007. – №132, Suppl. 3. – P. 29-55.Ames B. Cancer prevention and diet: Help from single nucleotide polymorphisms / B. Ames // Proc. Natl. Acad. Sci. USA. – 1999. – Vol. 96. –P. 12216-12218.Ames B. Cancer prevention and diet: Help from single nucleotide polymorphisms / B. Ames // Proc. Natl. Acad. Sci. USA. – 1999. – Vol. 96. –P. 12216-12218.Bardin-Mikolajczak A. Occupation and risk of lung cancer in Central and Eastern Europe: the IARC multi-center case-control study / A. BardinMikolajczak, J. Lissowska, D. Zaridze, V. Janout, J. Fevotte et al. // Cancer Causes Control. – 2007. – Vol. 18. – P. 645-654.Bardin-Mikolajczak A. Occupation and risk of lung cancer in Central and Eastern Europe: the IARC multi-center case-control study / A. BardinMikolajczak, J. Lissowska, D. Zaridze, V. Janout, J. Fevotte et al. // Cancer Causes Control. – 2007. – Vol. 18. – P. 645-654.Beveridge R. Lung cancer risk associated with occupational exposure to nickel, chromium VI, and cadmium in two population-based casecontrol studies in Montreal / R. Beveridge, J. Pintos , M.E. Parent, J. Asselin , J. Siemiatycki //Am. J. Ind. Med. – 2010. – Vol. 53(5). – P. 476-485.Beveridge R. Lung cancer risk associated with occupational exposure to nickel, chromium VI, and cadmium in two population-based casecontrol studies in Montreal / R. Beveridge, J. Pintos , M.E. Parent, J. Asselin , J. Siemiatycki //Am. J. Ind. Med. – 2010. – Vol. 53(5). – P. 476-485.Boffetta P. Involuntary smoking and lung cancer / P. Boffetta // Scan. J. Work Environ. Health. – 2002. – Vol. 28 (Suppl 2). – P. 30–40.Boffetta P. Involuntary smoking and lung cancer / P. Boffetta // Scan. J. Work Environ. Health. – 2002. – Vol. 28 (Suppl 2). – P. 30–40.Boffetta P. Cancer of the lung, larynx and pleura. In: Textbook of cancer epidemiology 2nd edn. / P. Boffetta, D. Trichopoulos / Eds. H.O. Adami, D. Hunter, D. Trichopoulos. – Oxford: Oxford University Press, 2008. – 782 p.Boffetta P. Cancer of the lung, larynx and pleura. In: Textbook of cancer epidemiology 2nd edn. / P. Boffetta, D. Trichopoulos / Eds. H.O. Adami, D. Hunter, D. Trichopoulos. – Oxford: Oxford University Press, 2008. – 782 p.Bond G.G. Dietary vitamin A and lung cancer: results of a case-control study among chemical workers / G.G. Bond, F.E. Thompson, R.R. Cook // Nutr. Cancer. – 1987. – № 9. – P. 109-121.Bond G.G. Dietary vitamin A and lung cancer: results of a case-control study among chemical workers / G.G. Bond, F.E. Thompson, R.R. Cook // Nutr. Cancer. – 1987. – № 9. – P. 109-121.Boyce J.D. Ionizing radiation / J.D. Boyce // Cancer Epidemiology and Prevention / Eds D. Schottenfeld, J. F. Fraumeni. – Oxford: University Press, 2006. – P. 259-293.Boyce J.D. Ionizing radiation / J.D. Boyce // Cancer Epidemiology and Prevention / Eds D. Schottenfeld, J. F. Fraumeni. – Oxford: University Press, 2006. – P. 259-293.Boyle P. Cancer incidence and mortality in Europe / P. Boyle, J. Ferlay // Ann. Oncol. – 2005. – Vol. 16. – P. 481-488.Boyle P. Cancer incidence and mortality in Europe / P. Boyle, J. Ferlay // Ann. Oncol. – 2005. – Vol. 16. – P. 481-488.Brennan P. High Cumulative Risk of Lung Cancer Death among Smokers and Nonsmokers in Central and Eastern Europe / P. Brennan, A. Crispo, D. Zaridze, N. Szeszenia-Dabrowska, P. Rudnai [et al.] // Am. J. Epidemiol. – 2006. – Vol. 164. – P. 1233-1241.Brennan P. High Cumulative Risk of Lung Cancer Death among Smokers and Nonsmokers in Central and Eastern Europe / P. Brennan, A. Crispo, D. Zaridze, N. Szeszenia-Dabrowska, P. Rudnai [et al.] // Am. J. Epidemiol. – 2006. – Vol. 164. – P. 1233-1241.Brennan P. A multicenter case-control study of diet and lung cancer among non-smokers / P. Brennan, C. Fortes, J. Butler [et al.] // Cancer Causes Control. –2000. – №11. – P. 49-58.Brennan P. A multicenter case-control study of diet and lung cancer among non-smokers / P. Brennan, C. Fortes, J. Butler [et al.] // Cancer Causes Control. –2000. – №11. – P. 49-58.Carel R. Occupational exposure to asbestos and man-made vitreous fibres and risk of lung cancer: a multicenter case-control study in Europe / R. Carel, A.C. Olsson, D. Zaridze, N. Szeszenia-Dabrowska, P. Rudnai, J. Lissowska, et al. // Occup. Environ. Med. – 2007. – Vol. 64. – P. 502-508.Carel R. Occupational exposure to asbestos and man-made vitreous fibres and risk of lung cancer: a multicenter case-control study in Europe / R. Carel, A.C. Olsson, D. Zaridze, N. Szeszenia-Dabrowska, P. Rudnai, J. Lissowska, et al. // Occup. Environ. Med. – 2007. – Vol. 64. – P. 502-508.Cassidy A. Occupational Exposure to Crystalline Silica and Risk of Lung Cancer. A Multicenter Case-Control in Europe / A. Cassidy, Mannetje, M. Martie van Tongeren, J.K. Field, D. Zaridze, N. Szeszenia-Dabrowska, T. Fletcher et al. // Epidemiology. –2007. – Vol. 18. – P. 36-43.Cassidy A. Occupational Exposure to Crystalline Silica and Risk of Lung Cancer. A Multicenter Case-Control in Europe / A. Cassidy, Mannetje, M. Martie van Tongeren, J.K. Field, D. Zaridze, N. Szeszenia-Dabrowska, T. Fletcher et al. // Epidemiology. –2007. – Vol. 18. – P. 36-43.Dumitrescu R. Undestending breast cancer risk – where do we stand in 2005? / R. Dumitrescu, I. Cotarla // J. Cell. Mol. Med. – 2005. – № 9. – P. 208-221.Dumitrescu R. Undestending breast cancer risk – where do we stand in 2005? / R. Dumitrescu, I. Cotarla // J. Cell. Mol. Med. – 2005. – № 9. – P. 208-221.Durusoy R. Lung cancer risk and occupational exposure to meat and live animals / R. Durusoy, P. Boffetta, A. Mannetje, D. Zaridze, N. Szeszenia-Dabrowska [et al.] // Int. J. Cancer. – 2006. – Vol. 118. – P. 2543-2547.Durusoy R. Lung cancer risk and occupational exposure to meat and live animals / R. Durusoy, P. Boffetta, A. Mannetje, D. Zaridze, N. Szeszenia-Dabrowska [et al.] // Int. J. Cancer. – 2006. – Vol. 118. – P. 2543-2547.Ferlay J. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008 / J. Ferlay, H.R. Bray, D. Forman, C. Mathers, M.D. Parkin // Int. J. Cancer. – 2010. –№ 127. – P. 2893-2917.Ferlay J. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008 / J. Ferlay, H.R. Bray, D. Forman, C. Mathers, M.D. Parkin // Int. J. Cancer. – 2010. –№ 127. – P. 2893-2917.Feskanich D. Prospective study of fruit and vegetable consumption and risk of lung cancer among men and women / D. Feskanich, R.G. Ziegler, D.S. Michaud [et al.] // J Natl. Cancer Inst. – 2000. – Vol. 92. – P. 1812– 1823.Feskanich D. Prospective study of fruit and vegetable consumption and risk of lung cancer among men and women / D. Feskanich, R.G. Ziegler, D.S. Michaud [et al.] // J Natl. Cancer Inst. – 2000. – Vol. 92. – P. 1812– 1823.Freedman N.D. Cigarette smoking and subsequent risk of lung cancer in men and women / N.D. Freedman, M.F. Leitzmann, A.R. Hollenbeck, A. Schatzkin, C. Abnet // Lancet Oncol. – 2008. – Vol. 9, № 7. – P. 649-656.Freedman N.D. Cigarette smoking and subsequent risk of lung cancer in men and women / N.D. Freedman, M.F. Leitzmann, A.R. Hollenbeck, A. Schatzkin, C. Abnet // Lancet Oncol. – 2008. – Vol. 9, № 7. – P. 649-656.Gan Q. Disease burden of adult lung cancer and ischaemic heart disease from passive tobacco smoking in China / Q. Gan, K. Smith, S. Hammond, Hu. Teh-wei // Tobacco Control. – 2007. –Vol. 16. – P. 417-422.Gan Q. Disease burden of adult lung cancer and ischaemic heart disease from passive tobacco smoking in China / Q. Gan, K. Smith, S. Hammond, Hu. Teh-wei // Tobacco Control. – 2007. –Vol. 16. – P. 417-422.Gavey D.S. Genetic epidemiology and public health: hope, hype and future prospects / D.S. Gavey, S. Ebrahim, S. Lewis [et al.] // Lancet. – 2005. – Vol. 366. –P.1484-1498.Gavey D.S. Genetic epidemiology and public health: hope, hype and future prospects / D.S. Gavey, S. Ebrahim, S. Lewis [et al.] // Lancet. – 2005. – Vol. 366. –P.1484-1498.GLOBOCAN 2008, International Agency for Research on Cancer [Электронный ресурс]. – Режим доступа: http://globocan.iarc.fr/GLOBOCAN 2008, International Agency for Research on Cancer [Электронный ресурс]. – Режим доступа: http://globocan.iarc.fr/Grens К. Air pollution tied to lung cancer in non-smokers / K. Grens // American Journal of Respiratory and Critical Care Medicine. – 2011. – №4. –P. 19.Grens К. Air pollution tied to lung cancer in non-smokers / K. Grens // American Journal of Respiratory and Critical Care Medicine. – 2011. – №4. –P. 19.Holick C.N. Dietary carotenoids, serum betacarotene, and retinol and risk of lung cancer in the alpha-tocopherol, beta-carotene cohort study / C.N. Holick, D.S. Michaud, R. StolzenbergSolomon [et al.] // Am. J. Epidemiol. – 2002. – Vol. 156. – P. 536-547.Holick C.N. Dietary carotenoids, serum betacarotene, and retinol and risk of lung cancer in the alpha-tocopherol, beta-carotene cohort study / C.N. Holick, D.S. Michaud, R. StolzenbergSolomon [et al.] // Am. J. Epidemiol. – 2002. – Vol. 156. – P. 536-547.Hu J. Risk factors for lung cancer among Canadian women who have never smoked / J. Hu, Y. Mao, D. Dryer et al. // Cancer Detect Prev. – 2002. – № 26. –P. 129-138.Hu J. Risk factors for lung cancer among Canadian women who have never smoked / J. Hu, Y. Mao, D. Dryer et al. // Cancer Detect Prev. – 2002. – № 26. –P. 129-138.Hursting S.D. Calorie restriction, Aging, and Cancer prevention: Mechanisms of Action and Applicability to Humans / S.D. Hursting, J.A. Lavigne, D. Berrigan, S.N. Perkins, J.C. Barrett // Annu. Rev. Med. – 2003. – Vol. 54. – P. 131-152.Hursting S.D. Calorie restriction, Aging, and Cancer prevention: Mechanisms of Action and Applicability to Humans / S.D. Hursting, J.A. Lavigne, D. Berrigan, S.N. Perkins, J.C. Barrett // Annu. Rev. Med. – 2003. – Vol. 54. – P. 131-152.Kleinerman R.A. Lung cancer and indoor exposure to coal and biomass in rural China / R.A. Kleinerman, Z. Wang, L. Wang, C. Metayer, S. Zhang, A.V. Brenner, S. Zhang, Y. Xia [et al.] // J. Occup. Environ. Med. – 2002. – Vol. 44, № 4. – P. 338-344.Kleinerman R.A. Lung cancer and indoor exposure to coal and biomass in rural China / R.A. Kleinerman, Z. Wang, L. Wang, C. Metayer, S. Zhang, A.V. Brenner, S. Zhang, Y. Xia [et al.] // J. Occup. Environ. Med. – 2002. – Vol. 44, № 4. – P. 338-344.Knekt P. Leanness and lung cancer risk / P. Knekt, M. Heliovaara, A. Rissanen [et al.] // Int. J Cancer. – 1991. – Vol. 49. – P. 208-213.Knekt P. Leanness and lung cancer risk / P. Knekt, M. Heliovaara, A. Rissanen [et al.] // Int. J Cancer. – 1991. – Vol. 49. – P. 208-213.Korte J.E. Dose-specific meta-analysis and sensitivity analysis of the relation between alcohol consumption and lung cancer risk / J.E. Korte, P. Brennan, S.J. Henley [et al.] // Am J Epidemiol. –2002. –Vol. 155. –P. 496-506.Korte J.E. Dose-specific meta-analysis and sensitivity analysis of the relation between alcohol consumption and lung cancer risk / J.E. Korte, P. Brennan, S.J. Henley [et al.] // Am J Epidemiol. –2002. –Vol. 155. –P. 496-506.Krewski D. Residential radon and risk of lung cancer: a combined analysis of 7 North American case-control studies / D. Krewski, J.H. Lubin, J.M. Zielinski [et al.] // Epidemiology. – 2005. – №16 (2). – P. 137-145.Krewski D. Residential radon and risk of lung cancer: a combined analysis of 7 North American case-control studies / D. Krewski, J.H. Lubin, J.M. Zielinski [et al.] // Epidemiology. – 2005. – №16 (2). – P. 137-145.London S.J. Isothiocyanates, glutathione S-transferase Ml and Tl polymorphisms, and lung-cancer risk: a prospective study of men in Shanghai, China / S.J. London, J.M. Yuan, F.L. Chung et al. // Lancet. – 2000. – Vol. 356. – P. 724-729.London S.J. Isothiocyanates, glutathione S-transferase Ml and Tl polymorphisms, and lung-cancer risk: a prospective study of men in Shanghai, China / S.J. London, J.M. Yuan, F.L. Chung et al. // Lancet. – 2000. – Vol. 356. – P. 724-729.Mannisto S. Dietary carotenoids and risk of lung cancer in a pooled analysis of seven cohort studies / S. Mannisto, S.A. Smith-Warner, D. Spiegelman [et al.] // Cancer Epidemiol. Biomarkers Prev. – 2004. – №13. – P. 40-48.Mannisto S. Dietary carotenoids and risk of lung cancer in a pooled analysis of seven cohort studies / S. Mannisto, S.A. Smith-Warner, D. Spiegelman [et al.] // Cancer Epidemiol. Biomarkers Prev. – 2004. – №13. – P. 40-48.Mao Y. Physical activity and the risk of lung cancer in Canada / Y. Mao, S. Pan, S.W. Wen [et al.] // Am. J Epidemiol. – 2003. – Vol. 158. – P. 564-575.Mao Y. Physical activity and the risk of lung cancer in Canada / Y. Mao, S. Pan, S.W. Wen [et al.] // Am. J Epidemiol. – 2003. – Vol. 158. – P. 564-575.Marchand L. Le. Intake of flavonoids and lung cancer / L. Le Marchand, S.P. Murphy, J.H. Hankin [et al.] // J Natl. Cancer Inst. – 2000. – Vol. 92. – P. 154-160.Marchand L. Le. Intake of flavonoids and lung cancer / L. Le Marchand, S.P. Murphy, J.H. Hankin [et al.] // J Natl. Cancer Inst. – 2000. – Vol. 92. – P. 154-160.Parkin Ed. by D. Cancer incidence in Five Continents, Vol. IX. / Ed. by D. Parkin, S. Whelan, J. Ferlay., L. Teppo, D. Thomas. – IARC. Sci publ. №160. – Lyon, 2009. – 897 p.Parkin Ed. by D. Cancer incidence in Five Continents, Vol. IX. / Ed. by D. Parkin, S. Whelan, J. Ferlay., L. Teppo, D. Thomas. – IARC. Sci publ. №160. – Lyon, 2009. – 897 p.Parkin D.M. The fraction of cancer attributable to lifestyle and environmental factors in the UK in 2010 / D.M. Parkin, L. Boyd, L.C. Walker // British Journal of Cancer. – 2011. – №105 (S2). – P.77-81.Parkin D.M. The fraction of cancer attributable to lifestyle and environmental factors in the UK in 2010 / D.M. Parkin, L. Boyd, L.C. Walker // British Journal of Cancer. – 2011. – №105 (S2). – P.77-81.Proctor R.N. Tobacco and the global lung cancer epidemic / R.N. Proctor // Nat. Rev. Cancer. – 2001. – Vol. 1. – P. 241-255.Proctor R.N. Tobacco and the global lung cancer epidemic / R.N. Proctor // Nat. Rev. Cancer. – 2001. – Vol. 1. – P. 241-255.Rushton L. The burden of occupational cancer in Great Britain / L. Rushton, S. Hutchings, T. Brown – Published by the Health and Safety Executive 10. – 2007. – 119 p.Rushton L. The burden of occupational cancer in Great Britain / L. Rushton, S. Hutchings, T. Brown – Published by the Health and Safety Executive 10. – 2007. – 119 p.Siemiaticki J. Occupation / J. Siemiaticki, L. Richardson, P. Boffetta // Cancer Epidemiology and Prevention / Eds. D. Schottenfeld, J.F. Fraumeni. –Oxford: University Press, 2006. – P. 222-354.Siemiaticki J. Occupation / J. Siemiaticki, L. Richardson, P. Boffetta // Cancer Epidemiology and Prevention / Eds. D. Schottenfeld, J.F. Fraumeni. –Oxford: University Press, 2006. – P. 222-354.Steenland K. Dying for work: the magnitude of US mortality from selected causes of death associated with occupation / K. Steenland [et al.] // American Journal of Occupational Medicine. – 2003. – Vol. 43. – P. 461–482.Steenland K. Dying for work: the magnitude of US mortality from selected causes of death associated with occupation / K. Steenland [et al.] // American Journal of Occupational Medicine. – 2003. – Vol. 43. – P. 461–482.Taylor R. Passive smoking and lung cancer: a cumulative metaanalysis / R. Taylor, R. Cumming, A. Woodward [et al.] // Aust. NZ J Public Health. – 2001. – Vol. 25. – P. 203-211.Taylor R. Passive smoking and lung cancer: a cumulative metaanalysis / R. Taylor, R. Cumming, A. Woodward [et al.] // Aust. NZ J Public Health. – 2001. – Vol. 25. – P. 203-211.Thun M.J. Tobacco / M.J. Thun, S.J. Henley // Cancer Epidemiology and Prevention / Eds. D. Schottenfeld, J.F. Fraumeni. – Oxford University Press, 2006. – P. 217-242.Thun M.J. Tobacco / M.J. Thun, S.J. Henley // Cancer Epidemiology and Prevention / Eds. D. Schottenfeld, J.F. Fraumeni. – Oxford University Press, 2006. – P. 217-242.

The authors declare that there are no conflicts of interest present.