ymjЯкутский медицинский журналYakut Medical Journal1813-19052312-1017ЯНЦ КМП10.1234/YMJ.2022.77.21ymj-164Research ArticleАКТУАЛЬНАЯ ТЕМАACTUAL TOPICПерекисное окисление липидов в развитии некоторых симптомов постковидного синдромаLipid peroxidation in the development of some symptoms of post-COVID syndromeГригорьеваА. А.GrigorievaA. A.

Григорьева Анастасия Анатольевна – м.н.с., Арктический медицинский центр ЯНЦ КМП.

Anastasia A. Grigorieva – junior researcher, Arctic Medical Center YSC CMP.

nastiagrigoryeva@gmail.comРумянцевЕ. К.RumyantsevE. K.

Румянцев Егор Константинович – м.н.с. АМЦ.

Egor K. Rumyantsev – junior researcher, AMC.

НиколаевВ. М.NikolaevV. M.

Николаев Вячеслав Михайлович – к.б.н., с.н.с.

Vyacheslav M. Nikolaev – Candidate of Biological Sciences, senior researcher.

ОлесоваЛ. Д.OlesovaL. D.

Олесова Любовь Дыгыновна – к.б.н., в.н.с., зав. лаб.

Lyubov D. Olesova – Candidate of Biological Sciences, freelance researcher, Head of the laboratory.

РомановаА. Н.RomanovaA. N.

Романова Анна Николаевна – д.м.н, директор ЯНЦ КМП.

Anna N. Romanova – MD, Director of the YSC CMP.

Якутский НЦ комплексных медицинских проблемРоссияYSC CMPRussian Federation202205022025018386Copyright © Григорьева А.А., Румянцев Е.К., Николаев В.М., Олесова Л.Д., Романова А.Н., 20252025Григорьева А.А., Румянцев Е.К., Николаев В.М., Олесова Л.Д., Романова А.Н.Grigorieva A.A., Rumyantsev E.K., Nikolaev V.M., Olesova L.D., Romanova A.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://ymj.elpub.ru/jour/article/view/164

Исследована связь перекисного окисления липидов с нарушением сна, тревогой и депрессией у жителей г. Якутска, переболевших COVID-19. Установлено, что окислительный стресс при COVID-19 из-за повышения уровня АФК в организме может привести к гипоксии и психоэмоциональным нарушениям, таким как тревога и депрессия.

The relationship of lipid peroxidation with sleep disturbance, anxiety and depression in Yakutsk residents who recovered from COVID-19 was studied. It has been established that oxidative stress in COVID-19 due to an increase in the level of ROS in the body can lead to hypoxia and psycho-emotional disorders such as anxiety and depression.

COVID-19малоновый диальдегидперекисное окисление липидовпостковидные последствиягипоксиясонтревогадепрессияокислительный стрессCOVID-19malondialdehydelipid peroxidationpost-COVID effectshypoxiasleepanxietydepressionoxidative stressИсследование проведено в рамках инициативного проекта Якутского научного центра комплексных медицинских проблем «Комплексная оценка здоровья пациентов, перенесших новую коронавирусную инфекцию COVID-19».This study was conducted as part of the initiative project of the Yakutsk Scientific Center for Complex Medical Problems "Comprehensive assessment of the health of patients who have undergone a new coronavirus infection COVID-19".ReferencesАндреева Л.И. Модификация метода определения перекисей липидов в тесте с тиобарбитуровой кислотой / Л.И. Андреева, А.А. Кожемякина, А.А. Кишкун // Лаборатор.дело. – 1988. -№11. – С. 41-43.Andreeva L.I. Modification of the method for determining lipid peroxides in the test with thiobarbituric acid / L.I. Andreeva, A.A. Kozhemyakina, A.A. Kishkun // Lab. - 1988. - No. 11. - P. 41-43.Отдаленные симптомы COVID-19 у жителей г. Якутска /Л.Д. Олесова, В.А. Макарова, Я.И. Яковлева [и др.] // Якутский медицинский журнал. -2021. - 3 (75).-2-21. С. 66-69 doi 10.25789/YMJ.2021.75.17Olesova L.D. Long-term symptoms of COVID-19 in residents of Yakutsk /L.D. Olesova, V.A. Makarova, Ya.I. Yakovleva [et al.] // Yakut medical journal 3 (75).-2-21. P. 66-69 doi 10.25789/YMJ.2021.75.17О возможности использования препаратов сукцинатов в условиях гипоксии при COVID-19 / Ю.П. Орлов, Н.В. Говорова, О.В. Корпачева [и др.] // Общая реаниматология. -2021.- №17(3). - С. 78-98. doi.org/10/15360/1813-9779-2021-3-78-98On the possibility of using succinate preparations in hypoxic conditions with COVID-19 / Yu.P. Orlov, N.V. Govorova, O.V. Korpacheva [et al.] // General resuscitation. -2021. - No. 17(3). - P. 78-98. doi.org/10/15360/1813-9779-2021-3-78-98COVID-19: Discovery, diagnostics and drug development / Tarik Asselah, David Durantel, Eric Pasmant [et al.] // Hepatol. – 2021. – Vol.74(1). - P.168-184. doi: 10.1016/j.jhep.2020.09.031COVID-19: Discovery, diagnostics and drug development / Tarik Asselah, David Durantel, Eric Pasmant [et al.] // Hepatol. – 2021. – Vol.74(1). - P.168-184. doi: 10.1016/j.jhep.2020.09.031Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72 314 cases from the Chinese Center for Disease Control and Prevention / Wu Z, Mc Googan JM // Jama. – 2020. - 323(13). - P. 1239–1242. doi: 10.1001/jama.2020.2648.Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72 314 cases from the Chinese Center for Disease Control and Prevention / Wu Z, Mc Googan JM // Jama. – 2020. - 323(13). - P. 1239–1242. doi: 10.1001/jama.2020.2648.COVID-19 and multiorgan failure: A narrative review on potential mechanisms / T. Mokhtari, E. Hassani, N. Ghaffari [et al.] // Mol Histol. - 2020. –Vol. 51(6) - P.1-16. DOI: 10.1007/s10735-020-09915-3COVID-19 and multiorgan failure: A narrative review on potential mechanisms / T. Mokhtari, E. Hassani, N. Ghaffari [et al.] // Mol Histol. - 2020. –Vol. 51(6) - P.1-16. DOI: 10.1007/s10735-020-09915-3COVID-19 pandemic and mental health consequences: Systematic review of the current evidence / N. Vindegaard , M. Eriksen Benros // Brain Behav Immun. -2020. - Vol.89. -P.531-542. doi: 10.1016/j.bbi.2020.05.048.COVID-19 pandemic and mental health consequences: Systematic review of the current evidence / N. Vindegaard , M. Eriksen Benros // Brain Behav Immun. -2020. - Vol.89. -P.531-542. doi: 10.1016/j.bbi.2020.05.048.Evaluation of oxidative stress level: total antioxidant capacity, total oxidant status and glutathione activity in patients with COVID-19 / B. Karkhanei, E. TalebiGhane, F. Mehri // New Microbes New Infect. – 2021. – Vol.42:100897. doi: 10.1016/j.nmni.2021.100897Evaluation of oxidative stress level: total antioxidant capacity, total oxidant status and glutathione activity in patients with COVID-19 / B. Karkhanei, E. TalebiGhane, F. Mehri // New Microbes New Infect. – 2021. – Vol.42:100897. doi: 10.1016/j.nmni.2021.100897Mitochondrial control of immunity: beyond ATP / Mehta MM, Weinberg SE, Chandel NS // Nat. Rev. Immunol. – 2017. – Vol.17. - P. 608– 620. doi: 10.1038/nri.2017.66Mitochondrial control of immunity: beyond ATP / Mehta MM, Weinberg SE, Chandel NS // Nat. Rev. Immunol. – 2017. – Vol.17. - P. 608– 620. doi: 10.1038/nri.2017.66Nervous system involvement after infection with COVID-19 and other coronaviruses / Yeshun Wu , Xiaolin Xu , Zijun Chen [et .all.] // Brain Behav Immun. – 2020. -Vol.87. P.18-22. doi: 10.1016/j.bbi.2020.03.031Nervous system involvement after infection with COVID-19 and other coronaviruses / Yeshun Wu , Xiaolin Xu , Zijun Chen [et .all.] // Brain Behav Immun. – 2020. -Vol.87. P.18-22. doi: 10.1016/j.bbi.2020.03.031Oxidative eustress and oxidative distress: Introductory remarks / H. Sies // Academic Press – 2020. - P. 3-12. doi: 10.1016/B978-0-12-818606-0.00001-8Oxidative eustress and oxidative distress: Introductory remarks / H. Sies // Academic Press – 2020. - P. 3-12. doi: 10.1016/B978-0-12-818606-0.00001-8Oxidative Stress as Key Player in Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) / L. Delgado-Roche, F. Mesta // Infection Archives of Medical Research -2020. -Vol.51, Issue 5. -P.384-387 doi.org/10.1016/j.arcmed.2020.04.019Oxidative Stress as Key Player in Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) / L. Delgado-Roche, F. Mesta // Infection Archives of Medical Research -2020. -Vol.51, Issue 5. -P.384-387 doi.org/10.1016/j.arcmed.2020.04.019Psychiatric and neuropsychiatric presentations associate with severe coronavirus infections: a systematic review and meta-analysis with comparison to the COVID-19 pandemic. / JP. Rogers, Е. Chesney, D. Oliver, [et al.] // Lancet Psychiatry. -2020. - 7(7). – P. 611-627. doi: 10.1016/S2215-0366(20)30203-0.Psychiatric and neuropsychiatric presentations associate with severe coronavirus infections: a systematic review and meta-analysis with comparison to the COVID-19 pandemic. / JP. Rogers, Е. Chesney, D. Oliver, [et al.] // Lancet Psychiatry. -2020. - 7(7). – P. 611-627. doi: 10.1016/S2215-0366(20)30203-0.The SARS-CoV-2 and mental health: From biological mechanisms to social consequences / D. Szcześniak , A. Gładka , B. Misiak , [et al.] // Prog Neuropsychopharmacol Biol Psychiatry. – 2021. -Vol.10;104:110046. doi:10.1016/j.pnpbp.2020.110046.The SARS-CoV-2 and mental health: From biological mechanisms to social consequences / D. Szcześniak , A. Gładka , B. Misiak , [et al.] // Prog Neuropsychopharmacol Biol Psychiatry. – 2021. -Vol.10;104:110046. doi:10.1016/j.pnpbp.2020.110046.

The authors declare that there are no conflicts of interest present.