ymjЯкутский медицинский журналYakut Medical Journal1813-19052312-1017ЯНЦ КМПymj-1635Research ArticleОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯORIGINAL RESEARCHАнализ клинических исходов некоторых гастродуоденальных заболеваний в Якутии: связь штаммов iceA1 Helicobacter pylori с ранним началом хронического гастритаAnalysis of the clinical outcomes of some gastroduodenal diseases in Yakutia: iceA1 strains of Helicobacter pylori relations with the early onset of chronic gastritisГотовцевН. Н.GotovtsevN. N.

Готовцев Ньургун Наумович – м.н.с.

Donzcrew@mail.ruБарашковН. А.BarashkovN. A.

Барашков Николай Алексеевич – к.б.н., зав. лаб.

barashkov2004@mail.ruСаввиноваК. Е.SavvinovaK. E.

Саввинова Кюнней Егоровна – студент Института естественных наук

Potapova.kyuna@mail.ruПакМ. В.PakM. V.

Пак Мария Владимировна – аспирант Медицинского института

АлексееваМ. П.AlexeevaM. P.

Алексеева Мавра Павловна – врач эндоскопист

ЛоскутоваК. С.LoskutovaK. S.

Лоскутова Кюнняй Саввична – к.м.н., зав. лаб.

ПшенниковаВ. Г.PshennikovaV. G.

Пшенникова Вера Геннадиевна – м.н.с.

pshennikovavera@mail.ruРафаиловА. М.RafailovA. M.

Рафаилов Адюм Михайлович – к.б.н., доцент ИЕН

archinay@mail.ruЛехановаС. Н.LekhanovaS. N.

Леханова Саргылана Николаевна – к.м.н., доцент МИ

КрюбезиЭ.CrubézyE.

Крюбези Эрик – MD, проф.

crubezy.eric@free.frФедороваС. А.FedorovaS. A.

Федорова Сардана Аркадьевна – д.б.н., зав. НИЛ Института естественных наук, с.н.с.

ЯНЦ КМПRussian FederationСВФУ им. М.К. АммосоваRussian FederationРБ№1-НЦМRussian FederationРБ №1-НЦМRussian FederationУниверситет Версаль-Сен-Кантен-ан-ИвелинFrance201620092025031417Copyright © Готовцев Н.Н., Барашков Н.А., Саввинова К.Е., Пак М.В., Алексеева М.П., Лоскутова К.С., Пшенникова В.Г., Рафаилов А.М., Леханова С.Н., Крюбези Э., Федорова С.А., 20252025Готовцев Н.Н., Барашков Н.А., Саввинова К.Е., Пак М.В., Алексеева М.П., Лоскутова К.С., Пшенникова В.Г., Рафаилов А.М., Леханова С.Н., Крюбези Э., Федорова С.А.Gotovtsev N.N., Barashkov N.A., Savvinova K.E., Pak M.V., Alexeeva M.P., Loskutova K.S., Pshennikova V.G., Rafailov A.M., Lekhanova S.N., Crubézy E., Fedorova S.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://ymj.elpub.ru/jour/article/view/1635

Приведены результаты изучения клинических исходов у пациентов с некоторыми гастродуоденальными заболеваниями в зависимости от аллельных вариантов гена iceA Helicobacter pylori. Штаммы iceA1 были идентифицированы в 65,2% случаев, а iceA2 – в 34,7%. Ассоциаций в зависимости от пола пациентов, их места рождения или проживания не выявлено. Однако статистически значимые отличия в распределении аллелей гена iceA были найдены в зависимости от возраста пациентов с хроническим гастритом (ХГ), в частности отмечена высокая выявляемость iceA1 среди подростков. Полученные результаты могут свидетельствовать о раннем начале ХГ у носителей штаммов iceA1, циркулирующих в Якутии.

The article presents the results of a study of clinical outcomes in patients with several gastroduodenal diseases, depending on the allelic variants of the gene iceA Helicobacter pylori. The iceA1 strains were identified in 65,2% cases and iceA2 – in 34,7% cases. We found no associations according to gender of patients, their place of birth or residence. However, statistically significant differences in the distribution of iceA gene alleles were found depending on age of patients with chronic gastritis. Obtained results may indicate the early onset of chronic gastritis on carriers of iceA1 strains circulating in Yakutia.

Helicobacter pyloriхронический гастритязвенная болезнь желудкаЯкутияген iceAHelicobacter pylorichronic gastritisduodenal ulcerSakha Republic (Yakutia)iceA geneРабота выполнена при поддержке проекта Министерства образования и науки РФ ГК №6.656.2014/К, при финансовой поддержке гранта «Научно-образовательный фонд поддержки молодых учёных Республики Саха (Якутия)» 201502010121, а также при поддержке гранта Главы Республики Саха (Якутия) молодым ученым, специалистам и студентам (№ 105-РГ от 8 февраля 2016 года).The work was supported by the project of the Ministry of Education and Science of the Russian Federation Civil Code №6.656.2014 / K, with the financial support of the grant "Scientific and Educational Foundation for Support of Young Scientists of the Republic of Sakha (Yakutia)" 201 502 010 121, and with the support of the grant of the Head of the Republic of Sakha (Yakutia), the young scientists, specialists and students (number 105‐RH February 8, 2016).ReferencesАлександрова С.Л. 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The authors declare that there are no conflicts of interest present.