ymjЯкутский медицинский журналYakut Medical Journal1813-19052312-1017ЯНЦ КМПymj-1449Research ArticleСЛУЧАЙ ИЗ ПРАКТИКИCLINICAL CASEХроническая воспалительная демиелинизирующая полиневропатия у пациентки с болезнью Шарко-Мари-Тута IА типаChronic Inflammatory Demyelinating Polyneuropathy in a Patient with Charcot‐ MARIE‐Tooth (CMT) Disease Type 1A: Case ReportПоповаТ. Е.PopovaT. E.

Попова Татьяна Егоровна – к.м.н., доцент ИПОВ

Popova Tatyana E. ‐ Ph.D., Associate Professor, Department of Medical Genetics and Clinical Neurophysiology, Institute of Postgraduate Education.

660021, ul. Karl Marx 124, Krasnoyarsk

tata2504@yandex.ruТаппаховА. А.TappakhovA. A.

Таппахов Алексей Алексеевич – врач невролог Клиники Медицинского института 

Tappahov Alexey A. ‐doctor‐neurologist Clinic Medical Institute FSAEI VPO

677000, ul. Oiunsky, d. 27, Yakutsk

dralex89@mail.ruНиколаеваТ. Я.NikolaevaT. Y.

Николаева Татьяна Яковлевна – д.м.н., зав. кафедрой МИ

Nikolayeva Tatiana Y. ‐ Doctor of Medical Sciences, Head of Department of Neurology and Psychiatry Medical Institute 

677000, ul. Oiunsky, d. 27, Yakutsk

tyanic@mail.ruШнайдерН. А.SchnayderN. A.

Шнайдер Наталья Алексеевна – д.м.н., проф., зав. кафедрой ИПОВ

Schneider Natalia A. ‐ MD, Professor, Head of Department of Medical Genetics and Clinical Neurophysiology, Institute of Postgraduate Education KrasGMU

660021, Krasnoyarsk, ul. Karl Marx 124

NASchnaider@yandex.ruПетроваМ. М.PetrovaM. M.

Петрова Марина Михайловна – д.м.н., проф., зав. кафедрой

Petrova Marina M. ‐ MD, Professor, Head of the Department of outpatient therapy and family medicine postgraduate education KrasGMU

660022, Krasnoyarsk, ul. P. Zheleznyaka, 1

stk99@yandex.ruПетроваА. Ю.PetrovaA. Yu.

Петрова Алена Юрьевна – врач невролог

Petrova Alena Y. ‐ neurologist 

677000, Yakutsk, ul. P.Alekseeva 83A

alenufka@rambler.ruОконешниковаЛ. Т.OkoneshnikovaL. T.

Оконешникова Людмила Тимофеевна – врач невролог высшей квалиф. категории, зав. отделением

Okoneshnikova Lyudmila T., Head of Neurology department

677000, Yakutsk, ul. P.Alekseeva 83A

okoneshnikovalt@rambler.ruПоповД. А.PopovD. A.

Попов Дыгын Александрович – врач отделения МРТ-диагностики

Popov Dygyn A. ‐ doctor of department MRI diagnosis 

677000, Yakutsk, ul. P.Alekseeva 83A

pdygyn@mail.ruКрасноярский гос. мед. университетРоссияKrasGMURussian FederationСВФУ им. М.К. АммосоваРоссияNorth‐Eastern Federal University named after MK AmmosovRussian FederationКрасноярский гос. мед. университетRussian FederationГБУ РС(Я) «Республиканская больница №2-Центр экстренной медицинской помощи»РоссияGBU Republic Sakha (Yakutia) "Republican Hospital №2‐ Center for Emergency Medical Aid»Russian Federation20151309202504106109Copyright © Попова Т.Е., Таппахов А.А., Николаева Т.Я., Шнайдер Н.А., Петрова М.М., Петрова А.Ю., Оконешникова Л.Т., Попов Д.А., 20252025Попова Т.Е., Таппахов А.А., Николаева Т.Я., Шнайдер Н.А., Петрова М.М., Петрова А.Ю., Оконешникова Л.Т., Попов Д.А.Popova T.E., Tappakhov A.A., Nikolaeva T.Y., Schnayder N.A., Petrova M.M., Petrova A.Y., Okoneshnikova L.T., Popov D.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://ymj.elpub.ru/jour/article/view/1449

В статье приводится собственное клиническое наблюдение пациента с хронической воспалительной демиелинизирующей полиневропатией, развившейся на фоне наследственной моторно-сенсорной полиневропатии Шарко-Мари-Тута 1 типа. Показано, что наличие хронической персистирующей герпетической инфекции как внешнесредового фактора, наслаиваясь на мутацию в гене PMP22 (белка периферического миелина), может привести к развитию аутоиммунного процесса, проявляющегося демиелинизирующим поражением периферических нервов конечностей и краниальных нервов.

We report a patient with chronic inflammatory demyelinating polyneuropathy (CIDP) developed against hereditary motor‐sensory polyneuropathy (Charcot‐Marie‐Tooth disease type 1A). It is shown that the presence of chronic persistent herpes infection, stratifying on the mutation in the gene PMP22 (peripheral myelin protein), may lead to the development of autoimmune process, manifested demyelinating lesions of the peripheral nerves of the limbs and cranial nerves. CIDP – an autoimmune disease characterized by lesions of the myelin sheath of peripheral nerves, it accounts for about 20‐50% of undiagnosed polyneuropathy. The literature discusses the contribution of viruses of the family Herpes Viridae to the development of CIDP. Charcot‐Marie‐Tooth disease (CMT) – a large group of hereditary diseases of the nervous system characterized by chronic progressive weakness and atrophy of distal limb muscles, reduced tendon reflexes, foot deformities and hands, changes in gait and sensory impairments.

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The authors declare that there are no conflicts of interest present.