ymjЯкутский медицинский журналYakut Medical Journal1813-19052312-1017ЯНЦ КМПymj-1437Research ArticleНАУЧНЫЕ ОБЗОРЫ И ЛЕКЦИИSCIENTIFIC REVIEWS AND LECTURESПатогенез желчнокаменной болезниThe Cholelithiasis PathogenesisТихоновД. Г.TikhonovD. G.

Тихонов Дмитрий Гаврильевич – д.м.н., проф., гл. н.с. НИИ здоровья 

Tikhonov Dmitry Gavrilevich ‐ prof., Senior Researcher, Health Research Institute

Yakutsk

Tikhonov.Dmitri@yandex.ruСВФУ им. М.К. АммосоваРоссия, M.K. Ammosov NEFURussian Federation201513092025049196Copyright © Тихонов Д.Г., 20252025Тихонов Д.Г.Tikhonov D.G.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://ymj.elpub.ru/jour/article/view/1437

Проведен поиск научных статей в открытых базах данных Pubmed, Europa Pubmed Central, eLIBRARY с помощью поисковых терминов «gallstones and pathogenesis», а также на русском языке «желчнокаменная болезнь», «холелитиаз». Для анализа отобраны статьи с высоким уровнем цитирования, посвященные патогенезу желчнокаменной болезни.

До настоящего времени не до конца выяснены механизмы образования стабильных ядер кристаллизации холестериновых камней. В последнее время появляется множество фактов, подтверждающих существенное значение эффекта Галкина − Чечулина в образовании зародышей кристаллизации холестериновых камней и роли в этом бактерий и воспалительных процессов.

The author reports his search for scientific papers in the open databases Pubmed, Europa Pubmed Central, eLIBRARY using the search terms «gallstones and pathogenesis», as well as Russian equivalents for “cholelithiasis”. For the analysis articles on the cholelithiasis pathogenesis with a high citation level were selected.

So far, the mechanisms of formation of stable nuclei of crystallization of cholesterol stones are not fully elucidated. Recently, there are many facts proving essential Galkin ‐ Chechulin effect in the formation of cholesterol stones crystal nuclei and the role of the bacteria and inflammation.

Thus, in the pathogenesis of gallstone disease, the Galkin‐Chechulin effect plays a significant role in the formation of stable crystallization nuclei (embryos). Such bilirubin containing microlites do not spontaneously dissolve and there may be no symptoms for decades, and in the event of the conditions, described by W.H. Admirand and D.M. Small they become nuclei of crystallization of cholesterol stones of macroscopic dimensions.

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The authors declare that there are no conflicts of interest present.