ymjЯкутский медицинский журналYakut Medical Journal1813-19052312-1017ЯНЦ КМП10.25789/YMJ.2022.79.01ymj-14Research ArticleОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯORIGINAL RESEARCHСезонные колебания уровня витамина D у пациентов с остеопорозомSeasonal vitamin D variations in osteoporosis patientshttps://orcid.org/0000-0001-8010-6777АхвердянЮ. Р.AkhverdyanYu. R.

Ахвердян Юрий Рубенович – к.м.н., с.н.с.

 

Akhverdyan Yuri R. – PhD in Medicine, Senior Researcher at the Laboratory of Methods for the Treatment and Prevention of Joint Diseases 

doctor_2001@mail.ruhttps://orcid.org/0000-0002-8864-9570ЗаводовскийБ. В.ZavodovskyB. V.

Заводовский Борис Валерьевич – д.м.н., зам. директора, зав. лаб.

 

Zavodovsky Boris V. – Doctor of Medical Sciences, head of the laboratory for treatment and prevention of joint diseases, Federal State Budget Scientific Institution Scientific Research Institute 

https://orcid.org/0000-0002-8799-2991ПапичевЕ. В.PapichevE. V.

Папичев Евгений Васильевич – к.м.н., н.с.

 

Papichev Evgeny V. – PhD in Medicine, researcher at the laboratory for treatment and prevention of joint diseases

https://orcid.org/0000-0002-3022-4166ПоляковаЮ. В.PolyakovaYu. V.

Полякова Юлия Васильевна – к.м.н., н.с.

 

Polyakova Julia V. – PhD in Medicine, researcher

https://orcid.org/0000-0002-0965-6060СивордоваЛ. Е.Sivordova L.E.L. E.

Сивордова Лариса Евгеньевна – к.м.н., в.н.с.

 

Sivordova Larisa E. – PhD in Medicine, leading researcher at the laboratory for the treatment and prevention of joint diseases 

ФГБНУ «НИИ КиЭР им. А.Б. Зборовского»РоссияFSBI A.B. Zborovsky RICERRussian Federation2022020220250358Copyright © Ахвердян Ю.Р., Заводовский Б.В., Папичев Е.В., Полякова Ю.В., Сивордова Л.Е., 20252025Ахвердян Ю.Р., Заводовский Б.В., Папичев Е.В., Полякова Ю.В., Сивордова Л.Е.Akhverdyan Y.R., Zavodovsky B.V., Papichev E.V., Polyakova Y.V., Sivordova L.E. L.E.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://ymj.elpub.ru/jour/article/view/14

Изучались сезонные колебания 25(OH) vit D у пациентов с остеопорозом. В обследованной нами группе больных были выявлены существенные сезонные колебания 25(OH) vit D, с помощью статистических методов анализа доказано влияние сезонного фактора на уровень 25(OH) vit D. Также в исследовании приведены данные о проценте гиповитаминоза витамина D в разные месяцы у жителей Волгоградской области. Это позволяет скорректировать медикаментозную терапию в течение года.

Objective

Objective: To study the seasonal variations of 25(OH) vit D in patients with osteoporosis.

Materials and methods

Materials and methods. We observed 396 patients diagnosed with osteoporosis/osteopenia aged 24 to 93 years. The diagnosis of OP was based on the clinical recommendations of Osteoporosis-2021 approved by the Ministry of Health of the Russian Federation. All patients underwent dual-energy X-ray absorptiometry using the Lunar DPX apparatus. Vitamin 25(OH)D3 levels were determined using the commercial 25-OH Vitamin D ELISA kit. For statistical data processing, the software packages "STATISTICA 10.0 for Windows" were used.

Results

Results. We have found that during the year most patients have significant seasonal changes in the 25(OH) vit D level. The minimum value was recorded in January and December (respectively, 50.85 and 55.83 nmol/l). We found significant differences in the concentration of 25(OH) vit D between patients who were observed in June and patients who were examined in the remaining months (p<0.001); as well as between patients examined in August and patients observed in the spring months (p<0.05). Similar significance was observed between July and April (p=0.037). It was found that the highest percentage of patients with vitamin D deficiency was observed in April and reached 16.67%. In the period from June to September, the frequency of hypovitaminosis was significantly lower and amounted to 1.92–3.7%. It was found that with increasing age of patients there is a gradual decrease in the level of 25(OH) vit D blood (r = 0.099, p = 0.049).

Findings

Findings. Based on the data obtained, it is recommended to carry out the prevention of vitamin D deficiency for the population of the Volgograd region. Prevention should be carried out from September to May, in accordance with international recommendations. These recommendations are especially relevant for older people.

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The authors declare that there are no conflicts of interest present.