ymjЯкутский медицинский журналYakut Medical Journal1813-19052312-1017ЯНЦ КМП10.25789/YMJ.2022.77.24ymj-138Research ArticleНАУЧНЫЕ ОБЗОРЫ И ЛЕКЦИИSCIENTIFIC REVIEWS AND LECTURESВозможности нейровизуализационных маркеров в диагностике болезни ПаркинсонаPossibilities of neuroimaging markers in the diagnosis of Parkinson's diseasehttps://orcid.org/0000-0001-7115-4275АветисовС. Э.AvetisovS. E.

Аветисов Сергей Эдуардович – акад. РАН, проф., д.м.н., науч. руковод.; зав. кафедрой

Avetisov Sergey Eduardovich – academician of the Russian Academy of Sciences, Professor, Ph.D.

https://orcid.org/0000-0002-2704-6282ИллариошкинС. Н.IllarioshkinS. N.

Иллариошкин Сергей Николаевич – член-кор. РАН, д.м.н., проф., зам. директора по научной работе, главный координатор 5-го неврол. отд.

Illarioshkin Sergey Nikolayevich – corresponding member, RAS, Ph.D.M., Prof, deputy director of science, chief coordinator of the 5th neurol. department

https://orcid.org/0000-0001-5692-1800СурнинаЗ. В.SurninaZ. V.

Сурнина Зоя Васильевна – к.м.н., с.н.с.

Surnina Zoya Vasilyevna – Candidate of Medical Sciences, senior researcher,

MEDZOE@yandex.ruhttps://orcid.org/0000-0002-5201-299XГеоргиевС.GeorgievS.

Георгиев Стефан – аспирант, хирург-офтальмолог

г. Якутск

Georgiev Stefan – PhD student of the Eye Diseases Research Institute, ophthalmologist

Yakutsk

https://orcid.org/0000-0003-3843-6435МоскаленкоА. Н.MoskalenkoA. N.

Москаленко Анна Николаевна – врач-невролог, аспирант

Moskalenko Anna Nikolayevna – neurologist, postgraduate student

ФГБНУ «НИИ глазных болезней»; ФГАОУ ВО «Первый МГМУ им. И.М. СеченоваРоссияSechenov 1st Moscow Medical University, Eye Diseases Research InstituteRussian FederationФГБНУ НЦНРоссияFederal State Budgetary Institution Neurology Scientific Center, the laboratory of neural cerebral structures; FBHNU NTNRussian FederationФГБНУ «НИИ глазных болезней»РоссияEye Diseases Research InstituteRussian FederationФГБНУ «НИИ глазных болезней»; ГАУ РС(Я) ЯРОКБРоссияYakut Republican Ophthalmologic ClinicRussian FederationФГБНУ НЦНРоссияEye Diseases Research InstituteRussian Federation202204022025029296Copyright © Аветисов С.Э., Иллариошкин С.Н., Сурнина З.В., Георгиев С., Москаленко А.Н., 20252025Аветисов С.Э., Иллариошкин С.Н., Сурнина З.В., Георгиев С., Москаленко А.Н.Avetisov S.E., Illarioshkin S.N., Surnina Z.V., Georgiev S., Moskalenko A.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://ymj.elpub.ru/jour/article/view/138

В обзоре в обобщенном виде представлены результаты исследований, касающихся применения принципа нейровизуализации для ранней диагностики болезни Паркинсона (БП). Термин «нейровизуализация» объединяет различные методы прямого или косвенного отображения структуры, функций и биохимических характеристик компонентов нервной системы. Индикация специфичных дефектов структур головного мозга стала возможной благодаря таким методам, как позитронно-эмиссионная томография, однофотонная эмиссионная компьютерная томография, транскраниальная сонография в B-режиме, МР-исследования головного мозга в режиме SWI, нейромеланинчувствительная МРТ. Глазной компонент нейровизуализации при БП может быть связан с исследованием структурно-функционального состояния различных нейроэлементов глаза, в частности с оценкой состояния нервных волокон роговицы (НВР). Сложности проведения исследований в этом направлении нейровизуализации связаны не только с достоверным выявлением изменений НВР при БП, но и с оценкой специфичности этих изменений с учетом их потенциальной полиэтиологичности.

The review summarizes the results of studies on applying the principle of neuroimaging for the early diagnosis of Parkinson's disease (PD). The term "neuroimaging" combines various methods of direct or indirect displaying the structure, functions and biochemical characteristics of the nervous system. In-dication of specific defects in brain structures has become possible due to such methods as positron emission tomography, single photon emission computed tomography, transcranial sonography in B-mode, MRI of the brain in SWI mode, and neuromelanin-sensitive MRI (NM-MRI). The ocular component of neuroimaging in PD may be associated with the study of the structural and functional state of various neuroelements of the eye, in particular, with the as-sessment of the state of the corneal nerve fibers (CNF). The difficulties of con-ducting research in this area of neuroimaging may be associated not only with the reliable detection of CNF changes in PD, but also with the assessment of the specificity of these changes, taking into account their potential polyetiolo-gy.

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The authors declare that there are no conflicts of interest present.