ymjЯкутский медицинский журналYakut Medical Journal1813-19052312-1017ЯНЦ КМПymj-1348Research ArticleНАУЧНЫЕ ОБЗОРЫ И ЛЕКЦИИSCIENTIFIC REVIEWS AND LECTURESВозможности применения оксида графена в качестве наноструктурного тушителя флуоресценции при разработке новых флуоресцентных тест-систем для ДНК-диагностикиCapabilities of Graphene Oxide Application as a Nanostructured Quencher at the Development of New Fluorescent Test Systems for DNA-DiagnosticsКузнецовА. А.KuznetsovA. A.

КУЗНЕЦОВ Артем Александрович – инженер-исследователь УНЛ «Геномная медицина» Клиники, н.с.

Kuznetsov Artem Aleksandrovich –engineer-researcher of Laboratory of Genome Medicine, Clinics, research associate 

kuznecov.artem@mail.ruМаксимоваН. Р.MaksimovaN. R.

МАКСИМОВА Надежда Романовна – д.м.н., зав. УНЛ «Геномная медицина»

Maksimova Nadezda Romanovna, Head of Laboratory of Genome Medicine

АлександровГ. Н.AleksandrovG. N.

АЛЕКСАНДРОВ Григорий Николаевич – н.с.

Alexandrov Grigory Nikolaevich, research associate of Graphene Nanotechnology Laboratory

СмагуловаС. А.SmagulovaS. A.

СМАГУЛОВА Светлана Афанасьевна – зав. 

Smagulova Svetlana Afanasievna, Head of Graphene Nanotechnology Laboratory

Северо-Восточный федеральный ун-т им. М.К. Аммосова; ЯНЦ КМПРоссияMedical Institute, NEFU named after M.K. Ammosov; YSC CMP SB RAMSRussian FederationСеверо-Восточный федеральный ун-т им. М.К. Аммосова; Клиника МИРоссияClinics of Medical Institute, NEFU named after M.K. AmmosovRussian FederationСеверо-Восточный федеральный ун-т им. М.К. Аммосова; УНТЛ «Графеновые нанотехнологии» ФТИ СВФУРоссияNEFU named after M.K. AmmosovRussian Federation201412092025047478Copyright © Кузнецов А.А., Максимова Н.Р., Александров Г.Н., Смагулова С.А., 20252025Кузнецов А.А., Максимова Н.Р., Александров Г.Н., Смагулова С.А.Kuznetsov A.A., Maksimova N.R., Aleksandrov G.N., Smagulova S.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://ymj.elpub.ru/jour/article/view/1348

Обзор посвящен описанию существующих в мире подходов к применению оксида графена в качестве наноструктурного тушителя флуоресценции для ДНК-диагностики однонуклеотидных полиморфизмов. Рассмотрены уникальные свойства оксида графена по отношению к ДНК, описаны варианты его использования в качестве замены молекулярным тушителям флуоресценции в классических тест-системах. Рассмотрен потенциал адаптации существующих подходов к применению в лабораторной ДНК-диагностике.

Review is devoted to the description of the world’s approaches of using graphene oxide as a nanostructured quencher for DNA diagnostics of SNPs. The unique properties of graphene oxide with respect to DNA and detailed options for its use as a replacement for molecular quenchers in classical test systems are described. The potential for adaptation of existing approaches for the laboratory DNA-diagnostic is considered.

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The authors declare that there are no conflicts of interest present.