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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ymj</journal-id><journal-title-group><journal-title xml:lang="ru">Якутский медицинский журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Yakut Medical Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1813-1905</issn><issn pub-type="epub">2312-1017</issn><publisher><publisher-name>ЯНЦ КМП</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.25789/YMJ.2018.62.32</article-id><article-id custom-type="elpub" pub-id-type="custom">ymj-1282</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>НАУЧНЫЕ ОБЗОРЫ И ЛЕКЦИИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>SCIENTIFIC REVIEWS AND LECTURES</subject></subj-group></article-categories><title-group><article-title>Генетические факторы предрасположенности к аутоиммунным тиреопатиям</article-title><trans-title-group xml:lang="en"><trans-title>Genetic factors of predisposition to autoimmune thyropathies</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сунхалырова</surname><given-names>Т. К.</given-names></name><name name-style="western" xml:lang="en"><surname>Sunkhalyrova</surname><given-names>T. K.</given-names></name></name-alternatives><bio xml:lang="ru"><p>СУНХАЛЫРОВА Татьяна Константиновна – м.н.с.</p></bio><bio xml:lang="en"><p>Sunkhalyrova Tatyana Konstantinovna - candidate of science</p><p>Yakutsk</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Додохов</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Dodokhov</surname><given-names>V. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>ДОДОХОВ Владимир Владимирович – с.н.с., к.б.н.,ст. преподаватель</p></bio><bio xml:lang="en"><p>Dodokhov Vladimir Vladimirovich - Senior Researcher, Candidate of Biological Sciences, Senior Lecturer</p><p>Yakutsk</p></bio><email xlink:type="simple">dodoxv@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Соловьева</surname><given-names>Н. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Solov’eva</surname><given-names>N. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>СОЛОВЬЕВА Наталья Алексеевна – к.м.н., с.н.с.</p></bio><bio xml:lang="en"><p>Solovyeva Natalia Alekseevna - Candidate of Medical Sciences, Senior Researcher</p><p>Yakutsk</p></bio><email xlink:type="simple">sonata608@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Павлова</surname><given-names>Н. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Pavlova</surname><given-names>N. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>ПАВЛОВА Надежда Ивановна – к.б.н., вед.н.с. – руковод.лаб.</p></bio><bio xml:lang="en"><p>Pavlova Nadezhda Ivanovna - Candidate of Biological Sciences, Leading Researcher, Head of the laboratory</p><p>Yakutsk</p></bio><email xlink:type="simple">solnishko_84@inbox.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Филиппова</surname><given-names>Н. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Filippova</surname><given-names>N. P.</given-names></name></name-alternatives><bio xml:lang="ru"><p>ФИЛИППОВА Наталья Павловна – к.б.н., доцент, н.с.</p></bio><bio xml:lang="en"><p>Filippova Natalia Pavlovna - candidate of biological sciences,associate professor, Researcher</p><p>Yakutsk</p></bio><email xlink:type="simple">inniah1970@list.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Неустроева</surname><given-names>Л. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Neustroeva</surname><given-names>L. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>НЕУСТРОЕВА Лена Михайловна – м.н.с.</p></bio><bio xml:lang="en"><p>Neustroeva Lena Mikhailovna - candidate of technical sciences</p><p>Yakutsk</p></bio><email xlink:type="simple">Nlm31@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Варламова</surname><given-names>М. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Varlamova</surname><given-names>M. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>ВАРЛАМОВА Марина Алексеевна – н.с.</p></bio><bio xml:lang="en"><p>Varlamova Marina Alekseevna - Researcher</p><p>Yakutsk</p></bio><email xlink:type="simple">varlamova.m@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дьяконова</surname><given-names>А. Т.</given-names></name><name name-style="western" xml:lang="en"><surname>D’yakonova</surname><given-names>A. T.</given-names></name></name-alternatives><bio xml:lang="ru"><p>ДЬЯКОНОВА Александра Тимофеевна – м.н.с.</p></bio><bio xml:lang="en"><p>Dyakonova Alexandra Timofeevna – Junior Researcher</p><p>Yakutsk</p></bio><email xlink:type="simple">dyakonovaa@bk.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Куртанов</surname><given-names>Х. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Kurtanov</surname><given-names>Kh. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>КУРТАНОВ Харитон Алексеевич – к.м.н., гл.н.с.-руковод. отд.</p></bio><bio xml:lang="en"><p>Kurtanov Khariton Alekseevich - Candidate of Medical Sciences, Chief Scientific Officer - Head of the Department of Molecular Genetics</p><p>Yakutsk</p></bio><email xlink:type="simple">hariton_kurtanov@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ЯНЦ КМП</institution><country>Россия</country></aff><aff xml:lang="en"><institution>YNC CMP</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ЯНЦ КМП; ФГБОУ ВО «Якутская ГСХА»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>YNC CMP</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2018</year></pub-date><pub-date pub-type="epub"><day>09</day><month>09</month><year>2025</year></pub-date><volume>0</volume><issue>2</issue><fpage>106</fpage><lpage>109</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Сунхалырова Т.К., Додохов В.В., Соловьева Н.А., Павлова Н.И., Филиппова Н.П., Неустроева Л.М., Варламова М.А., Дьяконова А.Т., Куртанов Х.А., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Сунхалырова Т.К., Додохов В.В., Соловьева Н.А., Павлова Н.И., Филиппова Н.П., Неустроева Л.М., Варламова М.А., Дьяконова А.Т., Куртанов Х.А.</copyright-holder><copyright-holder xml:lang="en">Sunkhalyrova T.K., Dodokhov V.V., Solov’eva N.A., Pavlova N.I., Filippova N.P., Neustroeva L.M., Varlamova M.A., D’yakonova A.T., Kurtanov K.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://ymj.elpub.ru/jour/article/view/1282">https://ymj.elpub.ru/jour/article/view/1282</self-uri><abstract><p>В статье представлен обзор литературы о генетических факторах предрасположенности к аутоиммунным тиреопатиям, основными из которых являются диффузный токсический зоб и аутоиммунный тиреоидит. Исследования последних лет позволили установить, что в развитии аутоиммунного процесса при аутоиммунной тиреопатии генетические факторы вносят весомый вклад.</p></abstract><trans-abstract xml:lang="en"><p>The article presents a review of the literature about the genetic factors of predisposition to autoimmune to thyroid disorders, the main of which are diffuse toxic goiter and autoimmune thyroiditis. Studies of recent years have made it possible to establish that genetic factors make a significant contribution to the development of the autoimmune process in autoimmune to thyroid disorders.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>заболевания эндокринной системы</kwd><kwd>аутоимунный тиреоидит</kwd><kwd>диффузный токсический зоб</kwd><kwd>генетические факторы</kwd><kwd>предрасположенность</kwd></kwd-group><kwd-group xml:lang="en"><kwd>endocrine system diseases</kwd><kwd>autoimmune thyroiditis</kwd><kwd>diffuse toxic goiter</kwd><kwd>genetic factors</kwd><kwd>predisposition</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Ассоциация полиморфных вариантов генов CYP1A1 и CYP1A2 с развитием репродуктивной и тиреоидной патологии у женщин-работниц нефтехимических производств / А.Р. 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