ymjЯкутский медицинский журналYakut Medical Journal1813-19052312-1017ЯНЦ КМП10.25789/YMJ.2018.62.27ymj-1277Research ArticleМЕТОДЫ ДИАГНОСТИКИ И ЛЕЧЕНИЯMETHODS OF DIAGNOSIS AND TREATMENTОпыт применения синтетических аналогов соматостатина при кровотечениях из варикозно расширенных вен пищевода у больных циррозом печени с синдромом портальной гипертензии в многопрофильном хирургическом центре РС(Я)Experience of synthetic analogues of somatostatine from esophageal variceal bleeding in patients with hepatic cirrhosis with syndrome of portal hypertension in the multidisciplinary surgical center of RS(Y)СавельевВ. В.SavelievV. V.

САВЕЛЬЕВ Вячеслав Васильевич – д.м.н., проф.

Savelyev Vyacheslav Vasilievich - MD, Professor of the Department of Faculty Surgery, Urology, Oncology andOtorhinolaryngology

677000, Yakutsk, ul. Belinsky, 58

Phone: 8 (4112) 35-20-90, fax: 8 (4112) 32-13-14

vvsavelievv@mail.ruВинокуровМ. М.VinokurovM. M.

ВИНОКУРОВ Михаил Михайлович – д.м.н., проф., зав. кафедрой

Vinokurov Mikhail Mikhailovich - MD, Professor, Head of the Department of Faculty Surgery, Urology, Oncology andOtorhinolaryngology

677000, Yakutsk, st. Dzerzhinsky 41, apt. 26

Phone: 8 (4112) 35-20-90, fax: 8 (4112) 32-13-14

mmv_mi@rambler.ruЕгороваВ. П.EgorovaV. P.

ЕГОРОВА Варвара Прокопьевна – аспирант

Egorova Varvara Prokopievna - postgraduate student of the Department of Faculty Surgery, Urology, Oncologyand Otorhinolaryngology

677000, Yakutsk, st. Dzerzhinsky 41/3, apt. 114

Phone: 8 (4112) 35-20-90, fax: 8 (4112) 32-13-14

varchik19@mail.ruЯлынскаяТ. В.YalynskayaT. V.

ЯЛЫНСКАЯ Татьяна Вадимовна – клинический ординатор

Yalynskaya Tatyana Vadimovna - clinical resident of the Department of Surgical Diseases and Dentistry of theFaculty of Postgraduate Education of Physicians

677009, Yakutsk, st. Dzerzhinsky 45/2, apt. 70

Phone: 8 (4112) 35-20-90, fax: 8 (4112) 32-13-14

barbuzyaka@mail.ruФГАОУ ВО «Северо-Восточный федеральный ун-т им. М.К. Аммосова»РоссияFGAOU VO «North-Eastern Federal University named after M.K. AmmosovRussian Federation201809092025029092Copyright © Савельев В.В., Винокуров М.М., Егорова В.П., Ялынская Т.В., 20252025Савельев В.В., Винокуров М.М., Егорова В.П., Ялынская Т.В.Saveliev V.V., Vinokurov M.M., Egorova V.P., Yalynskaya T.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://ymj.elpub.ru/jour/article/view/1277

Для оценки эффективности вазоактивной терапии синтетическими аналогами соматостатина при кровотечениях из варикозно расширенных вен пищевода проведен ретроспективный анализ результатов комплексного лечения пациентов с циррозом печени и синдромом портальной гипертензии. Представленный клинический опыт применения синтетических аналогов соматостатина в комплексной терапии при кровотечениях из варикозно расширенных вен пищевода позволяет рекомендовать их широкое использование в практике ургентных хирургических клиник.

The aim of the study was to evaluate the effectiveness of vasoactive therapy with synthetic somatostatin analogues from acute esophageal variceal bleeding in patients with hepatic cirrhosis with portal hypertension syndrome.

Material and methods

Material and methods. The study is based on a retrospective analysis of the results of a comprehensive treatment of 57 patients with cirrhosis and portal hypertension syndrome who were on treatment at the emergency surgical department of the Republican Hospital №2 − the Center for Emergency Medical Care of the Republic of Sakha (Yakutia) in the period from 2015 to 2017.All patients were divided into two groups. The first group consisted of 23 (40,4%) patients, who only used the Sengstaken-Blakemore probe to stop from acute esophageal variceal bleeding. The second group of the study comprised 34 (59,6%) patients who, together with the Sengstaken-Blakemore probe installation, used synthetic somatostatin analogues in complex intensive therapy.

Results

Results.The presented clinical experience of the use of synthetic somatostatin analogues in complex therapy from acute esophageal variceal bleedingto recommend their wide use in the practice of urgent surgical clinics.

Conclusion

Conclusion. The introduction of complex intensive therapy from acute esophageal variceal bleeding in patients with hepatic cirrhosis with the syndrome of portal hypertension of synthetic somatostatin analogues allowed to reduce the overall lethality to 10,7%, and to reduce the risk of rebleeding by 17%.

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The authors declare that there are no conflicts of interest present.