ymjЯкутский медицинский журналYakut Medical Journal1813-19052312-1017ЯНЦ КМП10.25789/YMJ.2018.62.14ymj-1264Research ArticleМАТЕРИАЛЫ НАУЧНО-ПРАКТИЧЕСКОЙ КОНФЕРЕНЦИИ С МЕЖДУНАРОДНЫМ УЧАСТИЕМ «ВЛИЯНИЕ ХОЛОДА НА ОРГАНИЗМ ЧЕЛОВЕКА»MATERIALS OF SCIENTIFIC-PRACTICAL CONFERENCE WITH INTERNATIONAL PARTICIPATION «THE INFLUENCE OF COLD ON THE HUMAN ORGANISM»Полиморфизм rs738409 гена адипонутрина (PNPLA3) среди коренных жителей СевераPolymorphism rs738409 of the adiponutrin gene (PNPLA3) among the indigenous residents of the NorthДьяконоваА. Т.DyakonovaA. T.

ДЬЯКОНОВА Александра Тимофеевна – м.н.с.

D’yakonova Aleksandra Timofeevna – Junior researcher of the laboratory of heritable pathology 

Tel.: 8 (914) 238 68 93

677010, Republic of Sakha (Yakutia), Yakutsk, Sergelyakhskoye shosse d.4

dyakonovaa@bk.ruПавловаН. И.PavlovaN. I.

ПАВЛОВА Надежда Ивановна – к.б.н., вед.н.с.-руковод. лаб.

Pavlova Nadezhda Ivanovna – PhD, temporary acting chief scientific officer - head of the laboratory of heritable pathology

Tel.: +7 (914) 289 39 36

677010, Republic of Sakha (Yakutia), Yakutsk, Sergelyakhskoye shosse d.4

solnishko_84@inbox.ruСоловьеваН. А.SolovyovaN. A.

СОЛОВьЕВА Наталья Алексеевна – к.м.н., с.н.с.

Solov’eva Natal’ya Alekseevna – PhD, temporary acting chief scientific officer - head of the Laboratory of Population Genetics

Tel.: 8 (924) 171 34 89

677010, Republic of Sakha (Yakutia), Yakutsk, Sergelyakhskoye shosse d.4

sonata608@yandex.ruФилипповаН. П.FilippovaN. P.

ФИЛИППОВА Наталья Павловна – к.б.н., доцент, с.н.с.

Filippova Natal’ya Pavlovna – PhD, associate professor, senior researcher of the Laboratory of Population Genetics

Tel.: 8 (914) 303 43 95

677010, Republic of Sakha (Yakutia), Yakutsk, Sergelyakhskoye shosse d.4

inniah1970@list.ruДодоховВ. В.DodokhovV. V.

ДОДОХОВ Владимир Владимирович – к.б.н., н.с.

Dodokhov Vladimir Vladimirovich – PhD, researcher of the Laboratory of Population Genetics

Tel.: 8 (964) 422 02

677010, Republic of Sakha (Yakutia), Yakutsk, Sergelyakhskoye shosse d.4

НеустроеваЛ. М.NeustroevaL. M.

НЕУСТРОЕВА Лена Михайловна – м.н.с.

Neustroeva Lena Mikhaylovna– Junior researcher of the laboratory of the Laboratory of Population Genetics 

Tel.: 8 (914) 825 26 01

677010, Republic of Sakha (Yakutia), Yakutsk, Sergelyakhskoye shosse d.4

ВарламоваМ. А.VarlamovaM. A.

ВАРЛАМОВА Марина Алексеевна – м.н.с.

Varlamova Marina Alekseevna – Junior researcher of the laboratory of heritable pathology

Tel.: 8 (914) 298 87 60

677010, Republic of Sakha (Yakutia), Yakutsk, Sergelyakhskoye shosse d.4

КуртановХ. А.KurtanovKh. A.

КУРТАНОВ Харитон Алексеевич – к.м.н., гл.н.с.-руковод. отдела

Kurtanov Khariton Alekseevich – PhD, Chief Scientific Officer - Head of the Department of Molecular Genetics

Tel.: +7 (914) 106 00 3

677010, Republic of Sakha (Yakutia), Yakutsk, Sergelyakhskoye shosse d.4

hariton_kurtanov@mail.ruФГБНУ «ЯНЦ КМП»РоссияFGBIU “Yakut Scientific Center of Complex Medical Problems”Russian Federation201809092025024547Copyright © Дьяконова А.Т., Павлова Н.И., Соловьева Н.А., Филиппова Н.П., Додохов В.В., Неустроева Л.М., Варламова М.А., Куртанов Х.А., 20252025Дьяконова А.Т., Павлова Н.И., Соловьева Н.А., Филиппова Н.П., Додохов В.В., Неустроева Л.М., Варламова М.А., Куртанов Х.А.Dyakonova A.T., Pavlova N.I., Solovyova N.A., Filippova N.P., Dodokhov V.V., Neustroeva L.M., Varlamova M.A., Kurtanov K.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://ymj.elpub.ru/jour/article/view/1264

С целью выявления неалкогольной жировой болезни печени (НАЖБП) был изучен полиморфизм rs738409 гена адипонутрина (PNPLA3) среди коренных жителей Севера в республике Саха (Якутия). Эпидемиологические данные свидетельствуют о частом сочетании СД 2 типа и НАЖБП, характеризующейся накоплением липидов как в самих гепатоцитах, так и в межклеточном пространстве. В последнее время большое значение придается генетической обусловленности НАЖБП.

In this paper, we analyzed the polymorphism rs738409 of the adiponuclein gene (PNPLA3) among the indigenous inhabitants of the North of the Republic of Sakha (Yakutia). Under the constant influence of low temperatures, the human body needs a high level of energy metabolism, which in turn is accompanied by a significant consumption of lipids. Epidemiological data indicate the frequent combination of type 2 diabetes and non-alcoholic fatty liver disease (NAFLD) characterized by accumulation of lipids both in the hepatocytes themselves and in the intercellular space. Recently, great importance is attached to the genetic conditionality of NAFLD.

сахарный диабет 2-го типаинсулинорезистентностьген адиопонутринаполиморфизмdiabetes mellitus type 2insulin resistanceadiponutrin genepolymorphismReferencesБирюкова Е.В. Сахарный диабет 2-го типа и неалкогольная жировая болезнь печени – болезни современности / Е.В. Бирюкова, С.В. Родионова // Медицинский альманах. – 2017. – № 6 (51). – С.130-135.Birjukova E.V., Rodionova S.V. Saharnyj diabet 2-go tipa I nealkogol’naja zhirovaj abolezn’ pecheni – bolezni sovremennosti [Diabetes mellitus type 2 and non-alcoholic fatty liver disease – diseases of the present]. Medicinskij al’manah [Medical almanac]. Moscow, 2017, № 6 (51), P.130-135.Исследование ассоциации полиморфизма гена PNPLA3c неалкогольной жировой болезнью печени в узбекской популяции / М.М. Каримов, Д.А. Далимова, Г.Н. Собирова [и др.] // Евразийский журнал внутренней медицины. – 2015. – № 02 (02). – С.25-27.Karimiv M.M., Dalimova D.A., Sobirova G.N., Saatov Z.Z., Hamdamova Sh.Zh. Issledovanie associacii polimorfizma gena PNPLA3 s nealkogol’noj zhirovoj bolezn’j u pecheni v uzbekskoj populjacii [The association study of polymorphism gene PNPLA3 with nonalcoholic fatty liver disease in the Uzbek population]. Evrazijskij zhurnal vnutrennej mediciny [Eurasian Journal of Internal Medicine]. Moscow, 2015, № 02 (02), P.25-27.Association of PNPLA3 SNP rs738409 with liver density in africanamericans with type 2 diabetes mellitus / AJ. Cox, MR. Wing, JJ. Carr, [et al.]Diabetes & metabolism. 2011. – Vol. 37,№5. – P.452-455. doi:10.1016/j.diabet.2011.05.001.Association of PNPLA3 SNP rs738409 with liver density in African Americans with type 2 diabetes mellitus / AJ. Cox, MR. Wing, JJ. Carr, [et al.] Diabetes & metabolism. 2011. – Vol. 37, №5. – P.452-455. doi: 10.1016/j.diabet.2011.05.001.Association of the rs738409 polymorphism in PNPLA3 with liver damage and the development of nonalcoholic fatty liver disease / K. Hotta, M. Yoneda, H. Hyogo [et al.] // BMC Med. Genet. – 2010. – Vol. 11. – P.172.Association of the rs738409 polymorphism in PNPLA3 with liver damage and the development of nonalcoholic fatty liver disease / K. Hotta, M. Yoneda, H. Hyogo [et al.] // BMC Med. Genet. – 2010. – Vol. 11. – P.172.Kan H. Influence of the rs738409 polymorphism in patatin-like phospholipase 3 on the treatment efficacy of non-alcoholic fatty liver disease with type 2 diabetes mellitus / H. Kan, H. Hyogo, H. Ochi // Hepatol Res. – 2016. – Vol.46– E146–E153. doi: 10.1111/hepr.12552.Specifically PNPLA3-Mediated Accumulation of Liver Fat in Obese Patients with Type 2 Diabetes / J-M. Petit, B. Guiu, D. Masson, L.[et al.] // The Journal of Clinical Endocrinology & Metabolism. – Vol. 95.– №12.– P.E430–E436 https:// doi.org/10.1210/jc.2010-0814Costs and consequence associatiated with newer medications for glycemic control in type 2 diabetes / A. Sinha, M. Ragan, T. Hoerger [et al.] // Diabetes Care.– 2010.– Vol. 33.– P. 695–700.Costs and consequence associated with newer medications for glycemic control in type 2 diabetes / A. Sinha M. Ragan, T. Hoerger [et al.] // Diabetes Care.– 2010.– Vol. 33.– P. 695–700.Specifically PNPLA3-Mediated Accumulation of Liver Fat in Obese Patients with Type 2 Diabetes / J-M. Petit, B. Guiu, D. Masson, L.[et al.] // The Journal of Clinical Endocrinology & Metabolism. – 2010. – Vol. 95.– №12.– P.E430– E436 https://doi.org/10.1210/jc.2010-0814Kan, H. Influence of the rs738409 polymorphism in patatin-like phospholipase 3 on the treatment efficacy of non-alcoholic fatty liver disease with type 2 diabetes mellitus / H. Kan, H. Hyogo, H. Ochi, // Hepatol Res.– Vol.46– E146–E153. doi: 10.1111/hepr.12552.The impact of PNPLA3 and JAZF1 on hepatocellular carcinoma in non-viral hepatitis patients with type 2 diabetes mellitus/ M. Ueyama, N. Nishida, M. Korenaga [et al.] //J Gastroenterol. –2015.– Vol.51(4).– 370-9. doi: 10.1007/s00535-015-1116-6. Epub 2015 Sep 3.The impact of PNPLA3 and JAZF1 on hepatocellular carcinoma in non-viral hepatitis patients with type 2 diabetes mellitus/ M. Ueyama, N. Nishida, M. Korenaga [et al.] //J Gastroenterol. –2015. – Vol.51(4).– 370-9. doi: 10.1007/ s00535-015-1116-6. Epub 2015 Sep 3.Association of PNPLA3 with non-alcoholic fatty liver disease in a minority cohort: the Insulin Resistance Atherosclerosis Family Study/ LE.Wagenknecht, ND.Palmer, DW.Bowden [et al.] // Liver international: official journal of the International Association for the Study of the Liver.– 2011.– Vol.31(3). – P.412-416. doi:10.1111/j.1478-3231.2010.02444.x.Association ofPNPLA3 with nonalcoholic fatty liver disease in a minority cohort: the Insulin Resistance Atherosclerosis Family Study/ LE.Wagenknecht, ND.Palmer, DW.Bowden [et al.] // Liver international: official journal of the International Association for the Study of the Liver. – 2011.– Vol.31(3). – P.412-416. doi:10.1111/j.1478-3231.2010.02444.x.http://www.internationalgenome.org/http://www.internationalgenome.org/

The authors declare that there are no conflicts of interest present.