ymjЯкутский медицинский журналYakut Medical Journal1813-19052312-1017ЯНЦ КМП10.25789/YMJ.2019.68.26ymj-1232Research ArticleАРКТИЧЕСКАЯ МЕДИЦИНАARCTIC MEDICINEМинеральная плотность костной ткани осевого скелета у женщин постменопаузального периода с избыточной массой телаMineral bone density of axial skeletal tissue in overweight postmenopausal womenЕпановВ. В.EpanovV. V.

Епанов Виктор Владимирович – к.м.н., доцент, зав. лаб. Клиники

Epanov Victor Vladimirovich, candidate of medical sciences, associate professor, head. Laboratory of Osteoporosis, Clinic of the Medical Institute

677027, 27 Oyunsky st.,Yakutsk, Ph. +7 (4112) 49-67-65. Mob. + 7(924)177-02-73

Viktor.epanov@mail.ruЕпановаА. А.EpanovaA. A.

Епанова Анастасия Александровна – к.м.н., доцент

Epanova Anastasia Aleksandrovna, candidate of medical sciences, associate professor of the Department of Hospital Surgery and Radiation Diagnostics of the Medical Institute

677027, 27 Oyunsky st.,Yakutsk, Ph. +7(4112)49-67-65

Epanova_aa@mail.ruБорисоваА. П.BorisovaA. P.

Борисова Аграфена Павловна – магистрант

Borisova Agrafena Pavlovna, graduate student of the department of public health and healthcare of the Medical Institute

677027, 27 Oyunsky st.,Yakutsk, Ph. +7(4112)49-67-65

Agusch050690@gmail.comКолосоваО. Н.KolosovaO. N.

Колосова Ольга Николаевна – д.б.н., проф., гл.н.с.

Kolosova Olga Nikolaevna, Doctor of Biological Sciences, Professor Chief Researcher, Laboratory of Ecological and Medical Biochemistry, Biotechnology and Radiobiology

677007 Republic of Sakha (Yakutia), 41th Lenin ave.Yakutsk. Ph. +7(924)177-29-12

Kololgonik@gmail.comМедицинский институт СВФУ им. М.К. АммосоваРоссияFederal State Autonomous Educational Institution of Higher Education "M. K. Ammosov NorthEastern Federal University", Medical InstituteRussian FederationМедицинский институт СВФУ им. М.К. АммосоваРоссияFederal State Autonomous Educational Institution of Higher Education "M. K. Ammosov North-Eastern Federal University"Russian FederationИБПК СО РАНРоссияInstitute of Biological Problems of Cryolithozone SB RASRussian Federation201929082025049296Copyright © Епанов В.В., Епанова А.А., Борисова А.П., Колосова О.Н., 20252025Епанов В.В., Епанова А.А., Борисова А.П., Колосова О.Н.Epanov V.V., Epanova A.A., Borisova A.P., Kolosova O.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://ymj.elpub.ru/jour/article/view/1232

В исследовании оценивалась взаимосвязь между ожирением и минеральной плотностью кости (МПК) осевого скелета у женщин в постменопаузальном периоде, проживающих в условиях Якутии. Выявлено, что индекс массы тела статистически значимо влияет на минеральную плотность костной ткани, при этом очень важно соотношение мышечной ткани и жировой ткани. Повышение минерализации костной ткани осевого скелета у женщин постменопаузального периода напрямую зависит от степени ожирения.

The study evaluated the relationship between obesity and mineral bone density (BMD) of the axial skeleton in postmenopausal period of women living in the conditions of Yakutia. It was revealed that the body mass index statistically significantly affects the mineral density of bone tissue, while the ratio of muscle tissue to adipose tissue is very important. The increased mineralization of the bone tissue of the axial skeleton in postmenopausal women directly depends on the degree of obesity.

плотность костной тканиожирениекомпозитный состав телаbone densityobesitycomposite body compositionРабота выполнена в рамках Государственного задания «Обеспечение проведения научных исследований» №19.9242.2017/ИТР.The work was performed as a part of the State Assignment “Ensuring the ConductReferencesАметов А.С. Заболевание эндокринной системы и остеопороз/ А.С. Аметов, Е.В. Доскина //Русский медицинский журнал. – 2004. – №17.1022с.Ametov A.S. Endocrine system disease and osteoporosis / A.S. Ametov, E.V. Doskina // Russian medical journal. – 2004. – №17. – 1022р.Диагностика и лечение остеопороза принципы использования костной денситометрии/ D.T. Baran, K.G. Faulkner, H.T. Genant. [et al.] // Остеопороз и остеопатии. –1998. – №3. С.10-16.Diagnosis and treatment of osteoporosis principles of bone densitometry using / D.T. Baran, K.G. Faulkner, H.T. Genant [et al.] // Osteoporosis and osteopathy. – 1998. – №3. – Р.10-16.Композитный состав тела, костная масса и адипокины у женщин в постменопаузе с разным кардиоваскулярным риском (SCORE) / П.А. Птичкина, И.А. Скрипникова, В.Е. Новиков, В.А. Метельская [и др.] // Остеопороз и остеопатии. – 2012. – №1. С.3-6.Composite body composition, bone mass and adipokines in postmenopausal women with different cardiovascular risk (SCORE) / P.A. Ptichkina, I.A. Skripnikova, V.E. Novikov, V.A. Metel'skaja [et al.] // Osteoporosis and osteopathy. -2012. - №1. -р. 3-6.Мисникова И.В. Саркопеническое ожирение / И.В. Мисникова, Ю.А.Ковалева, Н.А. Климина // Русский медицинский журнал. – 2017. – №1. С.24-29.Misnikova I.V. Sarcopenic obesity / I.V. Misnikova, Yu.A Kovaleva, N.A.Klimina // Russian Medical Journal. -2017.- №1.– р.24-29.Остеопороз: диагностика, профилактика и лечение /под ред. Л.И. Беневоленской, О.М. Лесняк. – М.: ГЭОТАР – Медиа, 2005. – 171 с.Osteoporosis: diagnosis, prevention and treatment / L.I. Benevolenskaya, O.M. Lesnyak // – M.: GEOTAR – Media, 2005. – 171р.Хаснулин В.И. Современные представления о механизмах формирования северного стресса у человека в высоких широтах/ В.И. Хаснулин, П. В. Хаснулин // Экология человека. – 2012. – №1. С3-11.Khasnulin V.I. Modern views on the mechanisms of the formation of northern stress in humans at high latitudes / V.I. Khasnulin, P.V. Khasnulin // Human Ecology. – 2012. – №1. – р. 3-11.Чигарькова О. В. Состояние костной ткани у женщин с ожирением в постменопаузе. Влияние снижения массы тела на минеральную плотность кости и показатели костного метаболизма: автореф. на соиск. учен. степ. канд. мед. наук (14.00.03) / Чигарькова Ольга Вячеславовна; Федеральное государственное учреждение Эндокринологический научный центр.- Москва, 2009. – 22с.Chigar'kova O. V. Bone tissue in postmenopausal obese women. The effect of weight loss on bone mineral density and bone metabolism: avtoref. na soisk. uchen. step. kand. med. nauk (14.00.03) / Chigar'kova Od'ga Vyacheslavovna; Federal State Institution Endocrinological Research Center. Moskva, – 2009. – 22 р.Шишкова В.Н. Ожирение и остеопороз / В.Н.Шишкова // Остеопороз и остеопатии.- 2011.-№1. С.21-26.Shishkova V.N. Obesity and osteoporosis / V.N. Shishkova // Osteoporosis and osteopathy.-2011. -№1. – р.21-26.Correlation of obesity and osteoporosis: effect of fat mass on the determination of osteoporosis/ L.J. Zhao, H. Jiang, C.J. Papasian, D. Maulik [et al.] // J. of bone and mineral research. -2008.-Vol.23, №1. – Р.17-29. doi:10.1359/jbmr.070813/Correlation of obesity and osteoporosis: effect of fat mass on the determination of osteoporosis/ L.J. Zhao, H. Jiang, C.J. Papasian, D. Maulik [et al.] // J. of bone and mineral research. -2008.-Vol.23, №1. – Р.17-29. doi:10.1359/jbmr.070813/Determinants of bone mineral density in older men and women: Body composition as mediator/ S.M. Pluijm, M. Visser, J.H. Smit [et al.] //J. Bone Miner. Res. – 2001.– Vol.16, №11. – Р. 2142-2151. doi: 10.1359/jbmr.2001.16.11.2142.Determinants of bone mineral density in older men and women: Body composition as mediator/ S.M. Pluijm, M. Visser, J.H. Smit [et al.] //J. Bone Miner. Res. – 2001.– Vol.16, №11. – Р. 2142-2151. doi: 10.1359/jbmr.2001.16.11.2142.Differences in Axial Bone-Mineral Density, Serum Levels of Sex Steroids, and Bone Metabolism between Postmenopausal and Age-Matched and Body Size-Matched Premenopausal Subjects / H. Ohta, T. Ikeda, T. Masuzawa, K. Makita [et al.] // Bone.-1993. - Vol. 14, №2. – Р.111-116.Differences in Axial Bone-Mineral Density, Serum Levels of Sex Steroids, and Bone Metabolism between Postmenopausal and Age-Matched and Body Size-Matched Premenopausal Subjects / H. Ohta, T. Ikeda, T. Masuzawa, K. Makita [et al.] // Bone.-1993. - Vol. 14, №2. – Р.111-116.Felson D.T. Effects of weight and body mass index on bone mineral density in men and women: the Framingham study / DT Felson, Y Zhang, MT Hannan, JJ Anderson// J Bone Miner Res. -1993.-Vol.8, №5. – Р. 567-573. doi: 10.1002/jbmr.5650080507 View ArticlePubMedGoogle ScholarFelson D.T. Effects of weight and body mass index on bone mineral density in men and women: the Framingham study / DT Felson, Y Zhang, MT Hannan, JJ Anderson// J Bone Miner Res. -1993.-Vol.8, №5. – Р. 567-573. doi: 10.1002/jbmr.5650080507 View ArticlePubMedGoogle ScholarEffects of the obese gene-product on body weight regulation in ob/ob mice/ M.A. Pelleymounter, M.J. Cullen, M.В. Baker, R. Hecht [et al.] //Science.-1995. -Vol.269, №3.-Р.540-543. doi: 10.1126/science.7624776Effects of the obese gene-product on body weight regulation in ob/ob mice/ M.A. Pelleymounter, M.J. Cullen, M.В. Baker, R. Hecht [et al.] //Science.-1995. -Vol.269, №3.-Р.540-543. doi: 10.1126/science.7624776Systemic bone loss and induction of coronary vessel disease in a rat model of chronic inflammation/ B.J. Smith, M.R. Lerner, S.Y. Bu, E.A. Lucas [et al.] // Bone. – 2006.– Vol.38, №3.– P.378–386. doi: 10.1016/j.bone.2005.09.008Systemic bone loss and induction of coronary vessel disease in a rat model of chronic inflammation/ B.J. Smith, M.R. Lerner, S.Y. Bu, E.A. Lucas [et al.] // Bone. – 2006.– Vol.38, №3.– P.378–386. doi: 10.1016/j.bone.2005.09.008Hofbauer L.C. Clinical implications of the osteoprotegerin / RANKL/RANK system for bone and vascular diseases/ L.C. Hofbauer, M. Schoppet // Jama-Journal of the American Medical Association. -2004.-Vol.292, №4. – Р. 490-495. doi: 10.1001/jama.292.4.490.Hofbauer L.C. Clinical implications of the osteoprotegerin / RANKL/RANK system for bone and vascular diseases/ L.C. Hofbauer, M. Schoppet // Jama-Journal of the American Medical Association. -2004.-Vol.292, №4. – Р. 490-495. doi: 10.1001/jama.292.4.490.Is adiposity advantageous for bone strength? A peripheral quantitative computed tomography study in late adolescent females/ N.K. Pollock, E.M .Laing, C.A. Baile, M.W. Hamrick [et al.] // Am J Clin Nutr. -2007.-Vol.86, №5. – Р. 1530-1538. doi: 10.1093/ajcn/86.5.1530Is adiposity advantageous for bone strength? A peripheral quantitative computed tomography study in late adolescent females/ N.K. Pollock, E.M .Laing, C.A. Baile, M.W. Hamrick [et al.] // Am J Clin Nutr. -2007.-Vol.86, №5. – Р. 1530-1538. doi: 10.1093/ajcn/86.5.1530Leptin, body composition and bone mineral density in premenopausal women/ M. Blum, S.S. Harris, A. Must, E.N. Naumova [et al.] // Calcif Tissue Int. -2003. – Vol. 73, №1. – Р.27-32. doi:10.1007/s00223-002-1019-4.View ArticlePubMedGoogle ScholarLeptin, body composition and bone mineral density in premenopausal women/ M. Blum, S.S. Harris, A. Must, E.N. Naumova [et al.] // Calcif Tissue Int. -2003. – Vol. 73, №1. – Р.27-32. doi:10.1007/s00223-002-1019-4.View ArticlePubMedGoogle ScholarLow body mass index is an important risk factor for low bone mass and increased bone loss in early postmenopausal women. Early Postmenopausal Intervention Cohort (EPIC) study group / P. Ravn, G .Cizza, N.H. Bjarnason, D. Thompson [et al.] // J Bone Miner Res. - 1999. – Vol.14, №9.– Р.1622-1627.doi:10.1359/jbmr.1999.14.9.1622.View ArticlePubMedGoogle ScholarLow body mass index is an important risk factor for low bone mass and increased bone loss in early postmenopausal women. Early Postmenopausal Intervention Cohort (EPIC) study group / P. Ravn, G .Cizza, N.H. Bjarnason, D. Thompson [et al.] // J Bone Miner Res. - 1999. – Vol.14, №9.– Р.1622-1627.doi:10.1359/jbmr.1999.14.9.1622.View ArticlePubMedGoogle ScholarNelson L.R. Estrogen production and action/ L.R. Nelson, S.E.Bulun //Journal of the American Academy of Dermatology. -2001. – Vol.45, №3. – Р.116-124. doi: 10.1067/mjd.2001.117432.PubMedGoogle ScholarNelson L.R. Estrogen production and action/ L.R. Nelson, S.E.Bulun //Journal of the American Academy of Dermatology. -2001. – Vol.45, №3. – Р.116-124. doi: 10.1067/mjd.2001.117432.PubMedGoogle ScholarObesity and fractures in postmenopausal women/ M.O. Premaor, L. Pilbrow, C. Tonkin [et al.] //J. Bone and Mineral Research. – 2010. – Vol.25, №2. – Р.292-297. doi: 10.1359/jbmr.091004Obesity and fractures in postmenopausal women/ M.O. Premaor, L. Pilbrow, C. Tonkin [et al.] //J. Bone and Mineral Research. – 2010. – Vol.25, №2. – Р.292-297. doi: 10.1359/jbmr.091004Overweight and obese children have low bone mass and area for their weight / A. Goulding, R.W. Taylor, I.E. Jones, K.A. McAuley [et al.] // Int J Obes Relat Metab Disord. – 2000. – Vol.24, №5. – Р.627-632. doi:10.1038/sj.ijo.0801207.View ArticlePubMedGoogle ScholarOverweight and obese children have low bone mass and area for their weight / A. Goulding, R.W. Taylor, I.E. Jones, K.A. McAuley [et al.] // Int J Obes Relat Metab Disord. – 2000. – Vol.24, №5. – Р.627-632. doi:10.1038/sj.ijo.0801207.View ArticlePubMedGoogle ScholarPoehlman ET. Menopause, energy expenditure, and body composition/ E.T. Poehlman// Acta Obstet Gynecol Scand. - 2002. Vol.81, №7. – Р.603-11. doi: 10.1034/j.1600-0412.2002.810705.xPoehlman ET. Menopause, energy expenditure, and body composition/ E.T. Poehlman// Acta Obstet Gynecol Scand. - 2002. Vol.81, №7. – Р.603-11. doi: 10.1034/j.1600-0412.2002.810705.xReid I.R. Relationspipes among body mass, its components, and bone/ I.R. Reid // Bone. – 2002. – Vol. 31, №5. – Р.547-555.Reid I.R. Relationspipes among body mass, its components, and bone/ I.R. Reid // Bone. – 2002. – Vol. 31, №5. – Р.547-555.Reid I.R. Volumetric bone density of the lumbar spine is related to fat mass but not lean mass in normal postmenopausal women/ I.R. Reid, M.C. Evans, R.W. Ames // Osteoporos Int. – 1994. – Vol. 4, №6. – Р.362-367. doi: 10.1007/BF01622199.View ArticlePubMedGoogle ScholarReid I.R. Volumetric bone density of the lumbar spine is related to fat mass but not lean mass in normal postmenopausal women/ I.R. Reid, M.C. Evans, R.W. Ames // Osteoporos Int. – 1994. – Vol. 4, №6. – Р.362-367. doi: 10.1007/BF01622199.View ArticlePubMedGoogle ScholarRelation of body composition, fat mass, and serum lipids to osteoporotic fractures and bone mineral density in Chinese men and women/Y.H. Hsu, S.A. Venners, H.A. Terwedow, Y. Feng, T. Niu [et al.] //Am J Clin Nutr. – 2006. – Vol.83, №1. – Р. 146-154. doi: 10.1093/ajcn/83.1.146 PubMedGoogle ScholarRelation of body composition, fat mass, and serum lipids to osteoporotic fractures and bone mineral density in Chinese men and women/Y.H. Hsu, S.A. Venners, H.A. Terwedow, Y. Feng, T. Niu [et al.] //Am J Clin Nutr. – 2006. – Vol.83, №1. – Р. 146-154. doi: 10.1093/ajcn/83.1.146 PubMedGoogle ScholarRobling A.G. Biomechanical and molecular regulation of bone remodeling/ A.G. Robling, A.B Castillo, C.H. Turner // Annual review of biomedical engineering. -2006. – №8. – Р. 455-498. doi: 10.1146/annurev.bioeng.8.061505.095721. View ArticlePubMedGoogle ScholarRobling A.G. Biomechanical and molecular regulation of bone remodeling/ A.G. Robling, A.B Castillo, C.H. Turner // Annual review of biomedical engineering. -2006. – №8. – Р. 455-498. doi: 10.1146/annurev.bioeng.8.061505.095721. View ArticlePubMedGoogle ScholarThe cerebrospinal fluid/serum leptin ratio during phannacological therapy for obesity/ A. M. Rodrigues, R. В. Radominski, L. Suplicy Hde, S. De Almeida [et al.] // J Clin Endocrinol Metab.-2002. – Vol. 87, №4. – Р.1621-6. doi: 10.1210/jcem.87.4.8420.The cerebrospinal fluid/serum leptin ratio during phannacological therapy for obesity/ A. M. Rodrigues, R. В. Radominski, L. Suplicy Hde, S. De Almeida [et al.] // J Clin Endocrinol Metab.-2002. – Vol. 87, №4. – Р.1621-6. doi: 10.1210/jcem.87.4.8420.The role of pro/anti-inflammatory adipokines on bone metabolism in NAFLD obese adolescents: effects of long-term interdisciplinary therapy / R.M Campos, A. Piano, P.L. Silva, J. Carnier [et al.] // Endocrine. – 2012. – Vol.42, №1. – Р.146-156. doi: 10.1007/s12020-012-9613-3.The role of pro/anti-inflammatory adipokines on bone metabolism in NAFLD obese adolescents: effects of long-term interdisciplinary therapy / R.M Campos, A. Piano, P.L. Silva, J. Carnier [et al.] // Endocrine. – 2012. – Vol.42, №1. – Р.146-156. doi: 10.1007/s12020-012-9613-3.

The authors declare that there are no conflicts of interest present.