ymjЯкутский медицинский журналYakut Medical Journal1813-19052312-1017ЯНЦ КМП10.25789/YMJ.2022.78.16ymj-121Research ArticleАКТУАЛЬНАЯ ТЕМАACTUAL TOPICИммунные реакции в зависимости от стадии онкологического заболеванияDependence of immune reactions on the stage of oncological diseaseДобродееваЛ. К.DobrodeevaL. K.

Добродеева Лилия Константиновна – д.м.н., проф., директор, гл.н.с.

г. Архангельск

Dobrodeeva Liliya Konstantinovna – MD, Prof., Director, Head of Scientific Research

Arkhangelsk

dobrodeevalk@mail.ruПатракееваВ. П.PatrakeevaV. P.

Патракеева Вероника Павловна – к.б.н., в.н.с.

г. Архангельск

Patrakeeva Veronika Pavlovna – Candidate of Biological Sciences, associate researche

Arkhangelsk

patrakeewa.veronika@yandex.ruСтрекаловскаяМ. Ю.StrekalovskayaM. Yu

Стрекаловская Марина Юрьевна – аспирант

г. Архангельск

Strekalovskaya Marina Yuryevna – postgraduate student

Arkhangelsk

mary.nesterowa2010@yandex.ruИнститут физиологии природных адаптаций ФГБУН ФИЦКИА РАН им. акад. Н.П. Лавёрова РАНРоссияN.P. Laverov Institute of Physiology of Natural Adaptations, Russian Academy of SciencesRussian Federation202204022025026064Copyright © Добродеева Л.К., Патракеева В.П., Стрекаловская М.Ю., 20252025Добродеева Л.К., Патракеева В.П., Стрекаловская М.Ю.Dobrodeeva L.K., Patrakeeva V.P., Strekalovskaya M.Y.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://ymj.elpub.ru/jour/article/view/121

Проведено обследование лиц с онкологическими заболеваниями различной локализации. Установлено, что иммунные реакции при злокачественных новообразованиях различаются в зависимости от стадии болезни. При начальных стадиях (I-II) развивается цитокиновая реакция, антителообразование с участием IgE на фоне ингибиции фагоцитарной активности, которая связана с переориентацией фагоцита на экзоцитоз. При III-IV стадиях рака активность цитокиновой и реагиновой реакций нарастает параллельно аутосенсибилизации. Для этого периода болезни характерно возрастание фагоцитарной активности нейтрофилов.

Patients with oncological diseases of various localization were examined. It has been established that immune responses in malignant neoplasms differ depending on the stage of the disease. At the initial stages (I-II), a cytokine reaction is noted, the antibody formation with IgE against the background of inhibition of phagocytic activity, which is associated with the reorientation of the phagocyte to exocytosis. At III-IV stages of cancer, the activity of cytokine and reagin reactions increases in parallel with autosensitization. This period of the disease is characterized by an increase in the phagocytic activity of neutrophils.

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The authors declare that there are no conflicts of interest present.