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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ymj</journal-id><journal-title-group><journal-title xml:lang="ru">Якутский медицинский журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Yakut Medical Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1813-1905</issn><issn pub-type="epub">2312-1017</issn><publisher><publisher-name>ЯНЦ КМП</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.25789/YMJ.2018.63.11</article-id><article-id custom-type="elpub" pub-id-type="custom">ymj-1114</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>МЕТОДЫ ДИАГНОСТИКИ И ЛЕЧЕНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>METHODS OF DIAGNOSIS AND TREATMENT</subject></subj-group></article-categories><title-group><article-title>Жесткость воды и ее взаимосвязь с уровнем онкомаркеров у жителей Якутии</article-title><trans-title-group xml:lang="en"><trans-title>The water hardness and its relationships with the level of tumor markers among the inhabitants of Yakutia</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ефремова</surname><given-names>С. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Efremova</surname><given-names>S. D.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ефремова Светлана Дмитриевна – м.н.с.</p></bio><bio xml:lang="en"><p>Efremova Svetlana Dmitrievna - Junior Researcher of the Laboratory of Immunology</p><p>677000 st. Sergelyakhskoye shosse, 4</p></bio><email xlink:type="simple">esd64@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гольдерова</surname><given-names>А. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Golderova</surname><given-names>A. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Гольдерова Айталина Семеновна – д.м.н., проф.</p></bio><bio xml:lang="en"><p>Golderova Aitalina Semenovna - Doctor of Medical Sciences</p><p>677000 st. Belinskogo</p></bio><email xlink:type="simple">hoto68@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кривошапкина</surname><given-names>З. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Krivoshapkina</surname><given-names>Z. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кривошапкина Зоя Николаевна – с.н.с.</p></bio><email xlink:type="simple">zoyakriv@mail.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Охлопкова</surname><given-names>Е. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Okhlopkova</surname><given-names>E. D.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Охлопкова Елена Дмитриевна – к.б.н., в.н.с.-руковод. лаб.</p></bio><bio xml:lang="en"><p>Okhlopkova Elena Dmitrievna - Candidate of Biology Science, Leading Researcher - Chief of the Immunology Laboratory</p><p>677000 st. Sergelyakhskoye shosse, 4</p></bio><email xlink:type="simple">elena_ohlopkova@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Николаев</surname><given-names>В. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Nikolaev</surname><given-names>V. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Николаев Вячеслав Михайлович – к.б.н, в.н.с.-руковод. отдела</p></bio><bio xml:lang="en"><p>Nikolaev Vyacheslav Mikhailovich - Candidate of Biology Science, Chief Researcher- Chief of DSAM</p><p>677000 st. Sergelyakhskoye shosse, 4</p></bio><email xlink:type="simple">Nikolaev1126@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Цыпандина</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Tsypandina</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Цыпандина Евгения Викторовна – м.н.с.</p></bio><bio xml:lang="en"><p>Tsypandina Evgenia Viktorovna - Junior Researcher of the Laboratory of Immunology</p><p>677000 st. Sergelyakhskoye shosse, 4</p></bio><email xlink:type="simple">tsypandina93@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Иванов</surname><given-names>П. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Ivanov</surname><given-names>P. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Иванов Петр Михайлович – д.м.н., с.н.с.</p></bio><bio xml:lang="en"><p>Ivanov Pyotr Mikhailovich - Doctor of Medical Science, senior researcher</p><p>677000 st. Sergelyakhskoye shosse, 4</p></bio><email xlink:type="simple">peter_ivanov_38@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сазонов</surname><given-names>Н. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Sazonov</surname><given-names>N. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Сазонов Николай Никитич – д.б.н.</p></bio><bio xml:lang="en"><p>Sazonov Nikolai Nikitich - Doctor of Biology Science</p><p>677000 st. Belinskogo</p></bio><email xlink:type="simple">nn.sazonov@s-vfu.ru</email><xref ref-type="aff" rid="aff-4"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБНУ «ЯНЦ КМП»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Federal State Budget Scientific Institution «Yakut Scientific Center of Complex Medical Problems»</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФТИ СВФУ им. М.К. Аммосова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>North-Eastern Federal University M.K. Ammosov</institution><country>Russian Federation</country></aff></aff-alternatives><aff xml:lang="ru" id="aff-3"><institution>ФГБНУ «ЯНЦ КМП»</institution><country>Russian Federation</country></aff><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>БГФ, СВФУ им. М.К. Аммосова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>North-Eastern Federal University M.K. Ammosov</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2018</year></pub-date><pub-date pub-type="epub"><day>28</day><month>08</month><year>2025</year></pub-date><volume>0</volume><issue>3</issue><fpage>37</fpage><lpage>39</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Ефремова С.Д., Гольдерова А.С., Кривошапкина З.Н., Охлопкова Е.Д., Николаев В.М., Цыпандина Е.В., Иванов П.М., Сазонов Н.Н., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Ефремова С.Д., Гольдерова А.С., Кривошапкина З.Н., Охлопкова Е.Д., Николаев В.М., Цыпандина Е.В., Иванов П.М., Сазонов Н.Н.</copyright-holder><copyright-holder xml:lang="en">Efremova S.D., Golderova A.S., Krivoshapkina Z.N., Okhlopkova E.D., Nikolaev V.M., Tsypandina E.V., Ivanov P.M., Sazonov N.N.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://ymj.elpub.ru/jour/article/view/1114">https://ymj.elpub.ru/jour/article/view/1114</self-uri><abstract><p>Проведена оценка степени взаимосвязи уровня онкомаркеров и жесткости употребляемой воды у жителей 6 различных районов Якутии. Проведенный анализ установил значимые прямые корреляционные связи между жесткостью воды и уровнем онкомаркеров: альфафетопротеина, раково-эмбрионального антигена, для мужчин простат-специфического антигена и для женщин углеводного антигена СА-125.</p></abstract><trans-abstract xml:lang="en"><p>The degree of the correlation between the level of oncomarkers and the rigidity of consumed water among residents of 6 different regions of Yakutia was assessed. The conducted analysis established significant direct correlation between water hardness and the level of oncomarkers: alfa-fetoprotein, cancer-embryonic antigen, prostate-specific antigen for men and carbohydrate antigen CA-125 for women.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>жесткость воды</kwd><kwd>онкомаркеры</kwd><kwd>Якутия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>water hardness</kwd><kwd>oncomarkers</kwd><kwd>Yakutia</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Бурцева Е.И. Геоэкологические аспекты развития Якутии / Е.И. Бурцева, Е.И. Петушкова. – Новосибирск: Наука, 2006. – 269 с.</mixed-citation><mixed-citation xml:lang="en">Burtseva E.I. Geoecological aspects of the development of Yakutia / E.I. Burtseva, E.I. 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