ymjЯкутский медицинский журналYakut Medical Journal1813-19052312-1017ЯНЦ КМП10.25789/YMJ.2023.83.08ymj-109Research ArticleМЕТОДЫ ДИАГНОСТИКИ И ЛЕЧЕНИЯMETHODS OF DIAGNOSIS AND TREATMENTВзаимосвязь системного уровня чемерина и клинико-лабораторных показателей у пациентов с ревматоидным артритомRelationship of the systemic level of chemerin and clinical - laboratory parameters in patients with rheumatoid arthritishttps://orcid.org/0000-0001-8010-6777АхвердянЮ. Р.AkhverdyanYu. R.

АХВЕРДЯН Юрий Рубенович – к.м.н., с.н.с.

Волгоград

AKHVERDYAN Yuri Rubenovich – PhD, senior researcher at the Laboratory of Methods for the Treatment and Prevention of Joint Diseases

Volgograd

doctor_2001@mail.ruhttps://orcid.org/0000-0002-8799-2991ПапичевЕ. В.PapichevE. V.

ПАПИЧЕВ Евгений Васильевич – к.м.н., н.с.

Волгоград

PAPICHEV Evgeny Vasilyevich – PhD, research associate at the Laboratory for Methods of Treatment and Prevention of Joint Diseases

Volgograd

https://orcid.org/0000-0002-8864-9570ЗаводовскийБ. В.ZavodovskyB. V.

ЗАВОДОВСКИЙ Борис Валерьевич – д.м.н., зам. директора, зав. лаб.

Волгоград

ZAVODOVSKY Boris Valeryevich – MD, Deputy director, head of the laboratory of methods of treatment and prevention of joint diseases

Volgograd

https://orcid.org/0000-0002-3022-4166ПоляковаЮ. В.PolyakovaJ. V.

ПОЛЯКОВА Юлия Васильевна – к.м.н., н.с.

Волгоград

POLYAKOVA Yulia Vasilyevna – PhD, research associate

Volgograd

https://orcid.org/0000-0002-0965-6060СивордоваЛ. Е.SeewordovaL. E.

СИВОРДОВА Лариса Евгеньевна – к.м.н., в.н.с.

Волгоград

SEEVORDOVA Larisa Evgenievna – PhD, visiting researcher leading researcher at the laboratory of methods for the treatment and prevention of joint diseases

Volgograd

НИИ клинической и экспериментальной ревматологии им. А.Б. ЗборовскогоРоссияFederal State Budgetary Institution Research Institute of Clinical and Experimental Rheumatology (FSBI RICER)Russian Federation202304022025033336Copyright © Ахвердян Ю.Р., Папичев Е.В., Заводовский Б.В., Полякова Ю.В., Сивордова Л.Е., 20252025Ахвердян Ю.Р., Папичев Е.В., Заводовский Б.В., Полякова Ю.В., Сивордова Л.Е.Akhverdyan Y.R., Papichev E.V., Zavodovsky B.V., Polyakova J.V., Seewordova L.E.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://ymj.elpub.ru/jour/article/view/109

Целью исследования было изучение взаимосвязи уровня чемерина в сыворотке крови и клинико-лабораторных показателей пациентов с ревматоидным артритом (РА). Выявлено, что уровень чемерина в сыворотке крови имеет прямую корреляцию с массой тела и индексом массы тела пациентов, с числом болезненных суставов, а также со средней годовой дозой глюкокортикостероидов. Средняя концентрация чемерина у пациентов с ранней стадией РА достоверно выше, чем у пациентов с развернутой стадией (р=0,037). Уровень чемерина достоверно выше у пациентов с РА, страдающих сахарным диабетом (p=0,007). Также выявлена корреляционная связь чемерина с уровнем СРБ (R=0,272758, p=0,010139).

Objective

Objective: to study the relationship between the level of chemerin in blood serum and clinical and laboratory parameters of patients with RA.

Materials and methods

Materials and methods. We observed 88 women diagnosed with RA, the average age was 56.4 years [47.5-60.7]. Disease activity according to DAS 28 was 3.50±1.11 (3.27-3.74) points. Articular erosions were present in 69 (78.4%) patients. Serum chemerin levels were determined using the commercial HUMAN CHEMERIN ELISA kit (BioVendor). Statistical processing was performed using the Statistica 12.0 software package for Windows.

Results

Results. The average level of chemerin in patients with RA was 463.5 ng/mL [366-576.5]. The level of chemerin in the blood serum has a direct correlation with the weight and BMI of patients, with the number of painful joints, as well as with the average annual dose of corticosteroids. The average concentration of chemerin in patients with an early stage of RA was significantly higher than in patients with an advanced stage (p=0.037). The difference between the level of chemerin in patients with early and late stages of RA is also close to statistically significant (p=0.066). The level of chemerin is significantly higher in RA patients with diabetes mellitus (p=0.007). The relationship was found chemerin with the level of CRP (Spearman - R=0.272758, p=0.010139). No correlations were found between the concentration of chemerin in the blood serum and the state of the bone tissue.

It can be assumed that chemerin is a typical pro-inflammatory adipokine that modulates inflammation in RA. In our study, in patients with RA, a positive correlation was found between the level of chemerin and weight, as well as BMI of patients. The level of chemerin is significantly higher in RA patients with diabetes mellitus.

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The authors declare that there are no conflicts of interest present.